PMID: 9450674Feb 5, 1998Paper

Progesterone increases levels of mu-opioid receptor mRNA in the preoptic area and arcuate nucleus of ovariectomized, estradiol-treated female rats

Brain Research. Molecular Brain Research
S L Petersen, K D LaFlamme

Abstract

Estradiol (E2) and progesterone (P) play different roles in generating the preovulatory surge release of luteinizing hormone-releasing hormone (LH-RH) and luteinizing hormone (LH). Results of our previous studies suggest that at least some of these steroid-specific effects may be mediated by beta-endorphinergic neurons. However, it is also possible that E2 and P differentially regulate responsiveness to opioids by altering mu-opioid receptor gene expression. To test this hypothesis, we used quantitative in situ hybridization histochemistry (ISHH) to measure the effects of E2 and P on mu-opioid receptor mRNA levels in cells of the preoptic area (POA) and arcuate nucleus (Arc). We examined several groups of animals in the morning and afternoon on the day of LH surge release: (1) 1-week ovariectomized (OVX) rats with or without E2 treatment sacrificed between 09:00 and 09:30 h (48 h after E2 capsules inserted); (2) OVX with or without E2 treatment sacrificed between 15:30 and 16:00 h; and (3) OVX with both E2 and P treatment sacrificed between 15:30 and 16:00 h (approximately 54 h after E2 and 6 h after P administration). We found that E2 had no effect on morning or afternoon levels of mu-opioid receptor mRNA levels in either the ...Continue Reading

References

Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Aug 1, 1971·Endocrinology·L CaligarisS Taleisnik
Dec 15, 1994·The Journal of Comparative Neurology·A MansourS J Watson
Jul 1, 1994·The Journal of Comparative Neurology·J M DelfsM F Chesselet

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Citations

Jun 25, 1999·Brain Research. Molecular Brain Research·M L Andria, E J Simon
Jun 14, 2006·Physiology & Behavior·Nino DevidzeDonald W Pfaff
May 19, 2011·Pharmacology, Biochemistry, and Behavior·K T TsutsuiR M Craft
Oct 4, 2016·Neurochemical Research·Carlos Villegas-GabuttiMarta Soaje
May 28, 2004·Molecular Psychiatry·J A Mong, D W Pfaff
Jul 19, 2008·Anesthesia and Analgesia·Albert DahanElise Sarton
Mar 11, 2020·Frontiers in Neuroanatomy·Mageswary SivalingamIshwar S Parhar

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