Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord

Journal of Neurotrauma
Florencia LabombardaAlejandro F De Nicola

Abstract

It is now widely accepted that progesterone (PROG) brings neuroprotection in lesions of the peripheral and central nervous system. Spinal cord trauma leads to neuronal degeneration, astrogliosis, demyelination, and proliferation of oligodendrocyte-precursor cells (OPCs). In this work, we studied the effects of PROG on myelin-related parameters in rats with complete spinal cord transection (TRX). To this end, sham-operated controls and rats with TRX at thoracic level T10 received vehicle or PROG (4 mg/kg/day) during 3 days. Three variables were measured in the lumbar L4 region below the lesion: (1) expression of myelin basic protein (MBP) at the protein and mRNA levels; (2) density of NG2-immunopositive cells as markers for OPCs; and (3) number of cells immunopositive for RIP, an antibody staining mature oligodendrocytes. TRX decreased MBP immunostaining in the corticospinal tract (CST) and dorsal ascending tract (DAT) but not the ventral funiculus (VF). NG2+ cells, which were detected in low number in controls, increased after TRX in the gray and white matter. RIP-positive cell number, however, remained unchanged. PROG treatment of rats with TRX enhanced the expression of MBP protein and mRNA in CST and DAT, but not VF and high...Continue Reading

References

Jan 1, 1985·Central Nervous System Trauma : Journal of the American Paralysis Association·A R Blight
Jun 9, 1995·Science·H L KoenigE E Baulieu
Nov 25, 1997·Journal of Neuropathology and Experimental Neurology·H S Keirstead, W F Blakemore
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J R ChanM Glaser
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·I Jung-TestasE E Baulieu
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·A NishiyamaB D Trapp
Feb 5, 2000·Progress in Neurobiology·R C MelcangiL Martini
Nov 4, 2000·Journal of Neurotrauma·M S BeattieJ C Bresnahan
Feb 13, 2001·Trends in Neurosciences·J M LevineJ W Fawcett
Feb 17, 2001·Current Opinion in Neurobiology·A E Fournier, S M Strittmatter
May 30, 2001·Brain Research. Molecular Brain Research·R GuennounM Schumacher
Jun 27, 2001·Journal of Neurocytology·M SchumacherE E Baulieu
Sep 11, 2001·Journal of Neuroscience Research·K IshiiK Uyemura
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R ChanE M Shooter
Apr 10, 2002·Journal of Neurotrauma·Florencia LabombardaAlejandro F de Nicola
Feb 15, 2003·Neurobiology of Disease·María Claudia Gonzalez DeniselleAlejandro F De Nicola
Sep 11, 2003·Developmental Neuroscience·Yangzhou DuCheryl F Dreyfus
Feb 14, 2004·Journal of Neuroendocrinology·I CirizaL M Garcia-Segura
Sep 8, 2004·Journal of Neuroscience Research·Ravi J TolwaniEric M Shooter

❮ Previous
Next ❯

Citations

Mar 30, 2010·Journal of Molecular Neuroscience : MN·Marzia PesaresiRoberto Cosimo Melcangi
Jul 23, 2013·Brain Research·Eric R DeutschDavid W Wright
Apr 30, 2009·Seminars in Reproductive Medicine·Paco S HersonPatricia D Hurn
May 15, 2008·Journal of Neurotrauma·Lesley K GilmerStephen W Scheff
Nov 5, 2008·Journal of the American Veterinary Medical Association·Jonathan M LevineNoah D Cohen
Jan 21, 2014·Experimental Neurology·Stella Elkabes, Arnaud B Nicot
Jul 31, 2007·Pharmacology & Therapeutics·Michael SchumacherAlejandro F De Nicola
Aug 28, 2015·Molecular Neurobiology·Sareh PandamoozLeila Dargahi
Sep 11, 2007·Brain Research Reviews·Donald G Stein
May 25, 2010·Journal of Neurochemistry·Donatella CarusoRoberto C Melcangi
Jun 16, 2010·Acta Neurologica Scandinavica·G Gargiulo MonachelliM C González Deniselle
Jan 31, 2012·Journal of Neuroendocrinology·S GiattiR C Melcangi
Aug 10, 2019·Neural Regeneration Research·Ignacio JureFlorencia Labombarda
May 6, 2020·International Journal of Molecular Sciences·Abdel Mouman GhoumariRashad Hussain
Dec 2, 2020·International Journal of Molecular Sciences·Eva FalvoSilvia Giatti
Mar 7, 2021·Biomolecules·Jocelyn M BretonDaniela Kaufer
Jan 19, 2007·Brain Research·Jeremy S TomaMatt S Ramer
Mar 26, 2009·Frontiers in Neuroendocrinology·Alejandro F De NicolaMichael Schumacher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.