Progesterone-independent activation of rat brain progestin receptors by reproductive stimuli

Endocrinology
A P AugerJ D Blaustein

Abstract

Activation of steroid hormone receptors by steroid hormones alters both the physiology and behavior of animals. Steroid hormone receptors (e.g., progestin receptors) can also be activated in the absence of steroid hormones by pharmacological treatment with neurotransmitters or neuropeptides. However, it is not known if progesterone-independent activation of brain progestin receptors occurs under natural, physiological, conditions. We report that increases in reproductive behavior and brain immediate early gene expression in female rats induced by mating stimuli can be blocked by prior treatment with progesterone antagonists in the absence of circulating progesterone. This suggests that progestin receptors are activated in a progesterone-independent manner by a physiologically relevant stimulus in female rats, thus implicating a novel pathway by which mating stimuli and other environmental influences could activate steroid receptors to influence neuronal response and behavior.

Citations

Apr 28, 2012·Neuroendocrinology·Shaila K Mani, Jeffrey D Blaustein
Jul 27, 2001·Hormones and Behavior·A L BennettJ D Blaustein
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·B Cenni, D Picard
Apr 7, 2010·Behavioural Brain Research·Fabiana Leopoldo de SousaMárcia Giovenardi
Feb 2, 2010·Frontiers in Neuroendocrinology·Shaila Mani, Wendy Portillo
Jul 22, 2004·Behavioural Brain Research·Mary S ErskineEva K Polston
Feb 4, 2009·Journal of Neuroendocrinology·S K ManiA Reyna
Jun 24, 2014·Hormones and Behavior·F J Lima-HernándezO González-Flores
Oct 25, 2016·Hormones and Behavior·Raymundo Domínguez-OrdóñezOscar González-Flores
Apr 9, 2010·Neuroreport·Luciano Mendoza-GarcésMarco A Cerbón
Nov 5, 2010·Endocrinology·Anthony P Auger, Catherine J Auger
Dec 31, 1998·Current Opinion in Neurology·R J Bicknell
May 15, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nelson R Cabej
Mar 3, 2004·Annals of the New York Academy of Sciences·Jeffrey D Blaustein
Aug 14, 2003·Scandinavian Journal of Psychology·Shaila Mani
Feb 18, 1998·Current Opinion in Neurobiology·L M Flanagan-Cato, S J Fluharty

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