PMID: 8962661Mar 1, 1996Paper

Progesterone induced blocking factor seen in pregnancy lymphocytes soon after implantation

American Journal of Reproductive Immunology : AJRI
J H CheckA O'Shaughnessy

Abstract

The immunomodulatory effect of progesterone (P) in pregnancy manifested via a protein named the P-induced blocking factor (PIBF) was previously reported. The goal of this study was to measure and compare the PIBF expression on lymphocytes between pregnant and non-pregnant women especially in early pregnancy. PIBF expression was determined by immunocytochemistry using a PIBF-specific polyclonal antibody. Levels were assessed during the mid-cycle, luteal phase, and first trimester of pregnancy. PIBF expression was found in 24.9% of mid-cycle sera, 49% of luteal phase sera of women who failed to conceive, and 75% of luteal phase sera of women who conceived. These data indicate that the percentage of PIBF expressing lymphocytes increases as a result of pregnancy and that the stimulus for PIBF induction occurs soon after implantation. These data support the concept that PIBF may play an important role in early implantation possibly by inhibiting the destructive function of natural killer lymphocytes.

References

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Citations

May 21, 2005·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
May 23, 2001·Fertility and Sterility·J H CheckN M Lamborne
Feb 24, 2000·Fertility and Sterility·A C EblenD D Taylor
Jun 16, 2001·International Immunopharmacology·J Szekeres-BarthoL Szereday
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·J H CheckJ Szekeres-Bartho
Jun 30, 1998·American Journal of Reproductive Immunology : AJRI·K KelemenJ Szekeres-Bartho
May 18, 1999·American Journal of Reproductive Immunology : AJRI·D A Clark
Feb 5, 2008·Journal of Reproductive Immunology·Ekaterina Ivanova-TodorovaStanimir D Kyurkchiev
Sep 29, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Christian J Gruber, Johannes C Huber
Jan 21, 2003·Biology of Reproduction·Donna Day BairdAllen J Wilcox
Mar 26, 2003·International Reviews of Immunology·Julia Szekeres-Bartho
Sep 1, 2013·Expert Review of Endocrinology & Metabolism·Jerome H Check, Rachael Cohen
Aug 1, 2002·American Journal of Reproductive Immunology : AJRI·David A ClarkReginald M Gorczynski
Jun 20, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mefkure Eraslan SahinCigdem Karakukcu

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