Progesterone-induced changes in sleep in male subjects

The American Journal of Physiology
E FriessR Rupprecht

Abstract

Progesterone administration induces a reduction of the vigilance state in humans during wakefulness. It has been been suggested that this effect is mediated via neuroactive metabolites that interact with the gamma-aminobutyric, acidA (GABAA) receptor complex. To investigate the effects of progesterone administration on the sleep electroencephalogram (EEG) in humans we made polysomnographic recordings, including sleep stage-specific spectral analysis, and concomitantly measured plasma concentrations of progesterone and its GABA-active metabolites 3 alpha-hydroxy-5 alpha-dihydroprogesterone (allopregnanolone) and 3 alpha-hydroxy-5 beta-dihydroprogesterone (pregnanolone) in nine healthy male subjects in a double-blind placebo-controlled crossover study. Progesterone administration at 9:30 PM induced a significant increase in the amount of non-rapid eye movement (REM) sleep. The EEG spectral power during non-REM sleep showed a significant decrease in the slow wave frequency range (0.4-4.3 Hz), whereas the spectral power in the higher frequency range (> 15 Hz) tended to be elevated. Some of the observed changes in sleep architecture and sleep-EEG power spectra are similar to those induced by agonistic modulators of the GABAA recepto...Continue Reading

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Citations

Jan 27, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·M Oettel, A K Mukhopadhyay
Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Michael I TrenellNaomi L Rogers
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H MurckF Holsboer
Jul 5, 2003·Physiological Reviews·Ralf M LoselMartin Wehling
Dec 22, 2020·Journal of Sleep Research·Christina Paula PlambergerKerstin Hoedlmoser

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