PMID: 3322376Dec 1, 1987Paper

Progesterone inhibition in mid-trimester termination of pregnancy: physiological and clinical effects

British Journal of Obstetrics and Gynaecology
M SelingerJ Ferguson

Abstract

A double-blind, placebo controlled clinical trial was conducted to assess the clinical and physiological effects of 'epostane', a progesterone synthesis inhibitor, in mid-trimester prostaglandin termination of pregnancy. Mean peripheral progesterone levels had fallen by 74% after 72 h in the patients treated wtih epostane. The mean induction-abortion interval in the treatment group was 490 (SD 271) min, compared with 1432 (SD 640) min in the control group. Intrauterine pressure recording demonstrated increased sensitivity to prostaglandin E2 after epostane treatment but no change in oxytocin sensitivity. The clinical implications of facilitated induction of abortion are discussed.

References

Jun 1, 1976·British Journal of Obstetrics and Gynaecology·I Z Mackenzie, M P Embrey
Jul 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A López BernalA C Turnbull

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Citations

Oct 23, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S C RobsonD Ronderos-Dumit
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·I Z Mackenzie
Jul 7, 2007·Seminars in Cell & Developmental Biology·Sam Mesiano, Toni N Welsh
Aug 1, 1991·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N C HillI Z MacKenzie
Jun 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·M Toppozada, A A Ismail
Aug 9, 2006·American Journal of Obstetrics and Gynecology·Alyssa A MillsAmy P Murtha
Mar 1, 1997·American Journal of Obstetrics and Gynecology·G J HaluskaM J Novy
Jan 1, 2009·Progress in Molecular Biology and Translational Science·J Julie KimSerdar E Bulun
May 4, 2004·Journal of the Society for Gynecologic Investigation·Sam Mesiano
Oct 5, 2010·Reproductive Sciences·Sam MesianoErrol R Norwitz
Jun 1, 1990·British Journal of Obstetrics and Gynaecology·N C HillI Z Mackenzie

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