PMID: 8604025Mar 1, 1996Paper

Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages

Journal of Leukocyte Biology
L MillerJ S Hunt

Abstract

The purpose of this study was to determine whether the female hormones estradiol-l7 beta (E2) and progesterone (P4) influence inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) by interferon-gamma(IFN-gamma)-and lipopolysaccharide (LPS)-activated mouse macrophages. Treatment with P4 alone caused a time- and dose-dependent inhibition of NO production by macrophage cell lines (RAW 264.7, J774) and mouse bone marrow culture-derived macrophages as assessed by nitrite accumulation. RAW 264.7 cells transiently transfected with an iNOS gene promoter/luciferase reporter-gene construct that were stimulated with IFN-gamma/LPS in the presence of P4 displayed reduced luciferase activity and NO production. Analysis of RAW 264.7 cells by Northern blot hybridization revealed concurrent P4-mediated reduction in iNOS mRNA. These observations suggest that P4-mediated inhibition of NO may be an important gender-based difference within females and males that relates to macrophage-mediated host defense.

Citations

Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D W Losordo, J M Isner
Feb 26, 2011·Immunological Reviews·Melba MunozMarkus M Heimesaat
Sep 4, 2010·Gastroenterology Research and Practice·Jane J Kim, Dorothy D Sears
Aug 27, 2013·Chimerism·Kimberly K MaKristina M Adams Waldorf
Feb 25, 2017·Frontiers in Immunology·Yong-Hong ZhangAi-Hua Liao
May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E VegetoA Maggi
Feb 22, 2001·American Journal of Physiology. Renal Physiology·R K Dubey, E K Jackson
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L L ReznikovC A Dinarello
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Shigeki ShimadaKazunori Onoé
Jul 4, 2001·Clinical Microbiology Reviews·C W RobertsJ Alexander
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Feb 19, 2010·American Journal of Reproductive Immunology : AJRI·Takeshi Nagamatsu, Danny J Schust
Nov 25, 2011·Infectious Diseases in Obstetrics and Gynecology·Bryan Larsen, Joseph Hwang
Aug 27, 2014·Nature Reviews. Rheumatology·Grant C Hughes, Divaker Choubey
Jul 23, 1999·Annals of the New York Academy of Sciences·E J GiltayB A Dijkmans
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·L Nathan, G Chaudhuri
Dec 3, 2008·American Journal of Reproductive Immunology : AJRI·Morgan R PeltierJohn C Smulian
Oct 1, 1996·Redox Report : Communications in Free Radical Research·M P ShermanL J Ignarro
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·K SampeiP D Hurn
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·John L MershonKenneth E Clark
Mar 28, 2006·Future Oncology·Alena Pance
Feb 19, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Juneo Freitas SilvaRogéria Serakides
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Cristiano BoitiAnna Gobbetti
Jul 31, 2008·Journal of Leukocyte Biology·A Sasha TaitEsther M Sternberg
Jul 26, 2014·Biology of Reproduction·Alison S CareSarah A Robertson
May 16, 2002·Parasite Immunology·Françoise Gay-AndrieuFrançois Peyron
Aug 13, 2015·American Journal of Obstetrics and Gynecology·Amy-Eunice FurcronNardhy Gomez-Lopez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.