Progesterone is neuroprotective by inhibiting cerebral edema after ischemia

Neural Regeneration Research
Yuan-Zheng ZhaoJianping Wang

Abstract

Ischemic edema can alter the structure and permeability of the blood-brain barrier. Recent studies have reported that progesterone reduces cerebral edema after cerebral ischemia. However, the underlying mechanism of this effect has not yet been elucidated. In the present study, progesterone effectively reduced Evans blue extravasation in the ischemic penumbra, but not in the ischemic core, 48 hours after cerebral ischemia in rats. Progesterone also inhibited the down-regulation of gene and protein levels of occludin and zonula occludens-1 in the penumbra. These results indicate that progesterone may effectively inhibit the down-regulation of tight junctions, thereby maintaining the integrity of the blood-brain barrier and reducing cerebral edema.

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Citations

Dec 2, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H LiJ Liu
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Junbin LinWeijing Liao
May 7, 2021·Critical Reviews in Food Science and Nutrition·Yiwen ChengZongxin Ling

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS Statistics

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