Progesterone mediates brain functional connectivity changes during the menstrual cycle-a pilot resting state MRI study

Frontiers in Neuroscience
Katrin ArelinJulia Sacher

Abstract

The growing interest in intrinsic brain organization has sparked various innovative approaches to generating comprehensive connectivity-based maps of the human brain. Prior reports point to a sexual dimorphism of the structural and functional human connectome. However, it is uncertain whether subtle changes in sex hormones, as occur during the monthly menstrual cycle, substantially impact the functional architecture of the female brain. Here, we performed eigenvector centrality (EC) mapping in 32 longitudinal resting state fMRI scans of a single healthy subject without oral contraceptive use, across four menstrual cycles, and assessed estrogen and progesterone levels. To investigate associations between cycle-dependent hormones and brain connectivity, we performed correlation analyses between the EC maps and the respective hormone levels. On the whole brain level, we found a significant positive correlation between progesterone and EC in the bilateral dorsolateral prefrontal cortex (DLPFC) and bilateral sensorimotor cortex. In a secondary region-of-interest analysis, we detected a progesterone-modulated increase in functional connectivity of both bilateral DLPFC and bilateral sensorimotor cortex with the hippocampus. Our result...Continue Reading

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Citations

Aug 15, 2015·Current Psychiatry Reports·Erika Comasco, Inger Sundström-Poromaa
Oct 8, 2016·Scientific Reports·Claudia BarthJulia Sacher
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Jan 3, 2020·Brain Structure & Function·Esmeralda Hidalgo-LopezBelinda Pletzer
Mar 25, 2018·Brain Structure & Function·Alessandra D NostroSimon B Eickhoff
Sep 9, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhenfu WenMohammed R Milad

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Methods Mentioned

BETA
contraception

Software Mentioned

LIPSIA
SPM8

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