PMID: 558037Apr 15, 1977Paper

Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat

Brain Research
I HanukogluR W Goy

Abstract

Specific brain regions, namely, thalamus, tectum, tegmentum, cerebellum, medulla and pineal, from five proestrous rats were incubated for 30 min with [3H]progesterone. After reverse isotopic dilution analysis, the following metabolites were identified in all incubations by purification to constant specific activity, derivative formation and/or gas liquid chromatography trapping: [3H]5alpha-pregnane-3, 20-dione (10-20% of the starting substrate except pineal -- 0.7%), [3H]3alpha-hydroxy-5alpha-pregnan-20-one (1.6-3.8% except for pineal -- 0.5%) and [3H]20alpha-hydroxy-4-pregnen-3-one (0.05-0.11%). Preliminary results from the corpus collosum incubation indicated the presence of the same metabolites. Although some apparent constant specific activities were obtained for 20alpha-hydroxy-5alpha-pregnan-3-one and 5beta-pregnane-3, 20-dione, the low levels of 3H associated with these steroids did not permit a definitive identification. The results indicate the presence of at least delta1-steroid 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities with progesterone as substrate in the brain regions examined.

References

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Citations

Dec 1, 1989·Steroids·A CarballeiraL M Fishman
Jan 1, 1983·Neurochemistry International·D P CardinaliP V Gejman
Jun 1, 1987·Brain Research Bulletin·S S SmithD J Woodward
Nov 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·L Martini, R C Melcangi
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·I Hanukoglu
Aug 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·M P CareyJ P Fry
Dec 18, 2001·Brain Research. Brain Research Reviews·S H MellonN A Compagnone
Dec 8, 2004·Experimental Gerontology·M ValléeW Mayo
Jul 9, 1984·Brain Research·C E Roselli, C A Snipes
Feb 9, 2000·Frontiers in Neuroendocrinology·N A Compagnone, S H Mellon
Jan 1, 1978·Journal of Endocrinological Investigation·D P Cardinali, M I Vacas

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