Progesterone plays a critical role in canine oocyte maturation and fertilization

Biology of Reproduction
Karine ReynaudSylvie Chastant-Maillard

Abstract

Canine oocyte maturation and fertilization take place within the oviducts under increasing plasma levels of progesterone (P4). In order to investigate the role of P4 in these processes, 51 beagle bitches were treated with the P4 receptor antagonist aglepristone at the end of proestrus and 32 females were kept untreated. Fifteen treated and 13 control bitches were inseminated at Days +1 and +2 after ovulation (Day 0). Stages of oocyte maturation and embryo development were determined after ovariectomy at different time points after ovulation. Aglepristone did not prevent ovulation but delayed the resumption of oocyte meiosis and inhibited its progression: first metaphase I (MI) stage was observed at 173 h postovulation and 39% of oocytes reached MII as late as 335 h postovulation in treated females whereas first MI occurred at 76 h and 100% of oocytes were in MII at 109 h postovulation in controls. Aglepristone extended the stay of morphologically normal oocytes within the oviducts: first signs of oocyte degeneration were observed at 335 h in treated versus 100- to 110-h postovulation in control bitches. In inseminated females, aglepristone prevented sperm progression toward the oviducts and fertilization, although motile sperma...Continue Reading

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Citations

Jan 8, 2020·International Journal of Molecular Sciences·Marie Saint-DizierPascal Mermillod
May 30, 2020·International Journal of Molecular Sciences·Marcia de Almeida Monteiro Melo FerrazNucharin Songsasen
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Jul 3, 2021·Animals : an Open Access Journal From MDPI·Piotr SochaTomasz Janowski

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