Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Peter KoulenMeharvan Singh

Abstract

The activity of cells critically depends on the control of their cytosolic free calcium ion (Ca(2+)) concentration. The objective of the present study was to identify mechanisms of action underlying the control of the gain of intracellular Ca(2+) release by circulating gonadal steroid hormones. Acute stimulation of isolated neurons with progesterone led to IP(3)R-mediated Ca(2+) transients that depend on the activation of the PI3 kinase/Akt/PKB signaling pathway. These results were confirmed at the molecular level and phosphorylation of IP(3)R type 1 by Akt/PKB was identified as the mechanism of action. Hence, it is likely that circulating gonadal steroid hormones control neuronal activity including phosporylation status through receptor- and kinase-mediated signaling. With a direct control of the gain of the Ca(2+) second messenger system as a signaling gatekeeper for neuronal activity the present study identifies a novel pathway for interaction of the endocrine and central nervous system.

References

Jul 1, 1991·Visual Neuroscience·H WässleF Müller
Nov 15, 1990·The Journal of Comparative Neurology·U GreferathH Wässle
Jan 16, 1985·Biochemical and Biophysical Research Communications·G Waloga, R E Anderson
Dec 1, 1994·The Journal of Physiology·A Feigenspan, J Bormann
Nov 1, 1993·Current Eye Research·N S DayR E Anderson
Oct 23, 1995·The Journal of Comparative Neurology·T Euler, H Wässle
May 13, 1996·Brain Research·M A Micci, B N Christensen
Sep 2, 1996·Neuroreport·C F VaqueroP de la Villa
Mar 1, 1997·The Journal of Physiology·M J Berridge
Jun 5, 1998·Trends in Pharmacological Sciences·M TreimanS B Christensen
Jul 17, 1998·Vision Research·J H BrandstätterH Wässle
Jul 24, 1998·Biophysical Journal·J Ramos-FrancoG A Mignery
Aug 11, 1998·Neuron·M J Berridge
Dec 5, 1998·Biochimica Et Biophysica Acta·C W Taylor
Jun 5, 1999·Molecular and Cellular Neurosciences·J C Perron, J L Bixby
Jun 23, 1999·Cell Calcium·S PatelA P Thomas
Jul 9, 1999·Vision Research·G Matthews
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·P KoulenJ H Brandstätter
Sep 18, 1999·The Journal of Membrane Biology·P Koulen
Oct 8, 1999·Progress in Biophysics and Molecular Biology·M Tachibana
Oct 27, 1999·The Keio Journal of Medicine·R A Shiells
Dec 22, 1999·Journal of Neurophysiology·W Shen, M M Slaughter
Dec 28, 1999·Brain : a Journal of Neurology·J Newsom-Davis
May 4, 2000·Acta Ophthalmologica Scandinavica·L A WickhamD A Sullivan
Sep 13, 2000·Molecular and Cellular Biology·C PeyssonnauxA Eychène
Feb 22, 2001·Journal of Neurochemistry·L E PolitiM F Insua

❮ Previous
Next ❯

Citations

Oct 22, 2008·Human Reproduction Update·B GellersenJ J Brosens
Mar 20, 2010·Acta Physiologica·D S KempeF Lang
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·R Scott DuncanPeter Koulen
Jun 4, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aiping Lan, Jie Du
Jan 27, 2011·Journal of Cellular Biochemistry·Marc-Olivier FrégeauGaétan Guillemette
Jun 23, 2010·Journal of Neuroscience Research·Miguel A R AmorimLuis M Garcia-Segura
Feb 19, 2010·American Journal of Physiology. Renal Physiology·Daniela S KempeFlorian Lang
Mar 20, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalia CheshenkoBetsy C Herold
Sep 12, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Stefania Taraborrelli
Apr 22, 2015·Reproduction, Fertility, and Development·Mariko KuseKiyoshi Okuda
Oct 21, 2016·The European Journal of Neuroscience·Alice C Wyse-JacksonThomas G Cotter
Oct 8, 2020·World Journal of Biological Chemistry·Indiwari Gopallawa, Robert J Lee
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Pablo CutiniVirginia Massheimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.