Progesterone, progestins and the breast in menopause treatment

Climacteric : the Journal of the International Menopause Society
A Gompel, G Plu-Bureau

Abstract

Breast cancer is the main risk associated with menopause hormone therapy (MHT). It is a hormone-dependent cancer. In postmenopausal women, about 80% of cases are estradiol receptor-positive. In cohort studies only estradiol receptor-positive breast cancers are promoted by MHT. Different levels of risk with estrogen-only treatment and combined treatment with estrogen + progestin are shown in randomized trials and observational studies. Several non-randomized studies show a lower risk with progesterone and retroprogesterone than with synthetic progestins. Progesterone and progestin are non-selective ligands for the progesterone receptor and bind also with other steroid receptors, with agonistic or antagonistic effects according to the structure of the molecule. Their half-life and metabolism are also different, progesterone being rapidly degraded with a short half-life. These aspects will be discussed in this review.

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Citations

Dec 16, 2019·The Journal of Clinical Endocrinology and Metabolism·Jennifer L GordonSusan S Girdler
Sep 23, 2020·Women & Health·Marcio Alexandre Hipolito Rodrigues, Anne Gompel
Mar 27, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Guiju CaiAlfred O Mueck
Mar 25, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·A GossetF Trémollieres
Oct 31, 2019·La Presse médicale·Anne Gompel
Jul 30, 2021·Clinical Obstetrics and Gynecology·Amy J VoedischJennifer Kasirsky

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