PMID: 8603052Jan 1, 1996Paper

Progesterone receptor A and B protein expression in human breast cancer

The Journal of Steroid Biochemistry and Molecular Biology
J D GrahamC L Clarke

Abstract

The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor which mediates progesterone action in target tissues. Two PR proteins, PR A (81-83 kDa) and PR B (116-120 kDa), have been described and different physiological activities ascribed to each on the basis of in vitro studies, suggesting that their ratio of expression may control progesterone responsiveness in target cells. Presence of PR in breast tumors is an important indicator of likely responsiveness to endocrine agents. However, the relative expression of PR A and B in breast cancer has not been described and its clinical significance has not been addressed. We have examined the expression of PR A and B in PR-positive breast tumors and found that while in most tumors PR A and B were expressed in similar amounts there was a broad overall distribution of PR A:B ratio which deviated significantly from a normal log distribution with tumors containing a PR A:B ration greater than 4 being over-represented in the group. Linear regression analysis revealed that high PR A:B ratios, in general, derived from a low concentration of PR B rather than high expression of PR A. PR A:B protein ratios were not correlated with the age of the patient or with to...Continue Reading

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Citations

Nov 23, 2006·Breast Cancer Research and Treatment·Fei XueKarin B Michels
Apr 16, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Larry N PetzAnn M Nardulli
Jun 23, 2001·Molecular and Cellular Endocrinology·O M ConneelyF J De Mayo
Jun 2, 1998·Molecular and Cellular Endocrinology·M C Keightley
Aug 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F M VerheijenM A Blankenstein
Jul 31, 2001·Journal of Clinical Pathology·P A MoteC L Clarke
Dec 3, 2009·Molecular Endocrinology·Jamie Bonéy-MontoyaAnn M Nardulli
Jan 17, 2008·Critical Reviews in Eukaryotic Gene Expression·Anastasia KariaginaSandra Z Haslam
Jul 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Biserka Mulac-Jericevic, Orla M Conneely
Nov 20, 2004·Obstetrics and Gynecology Clinics of North America·Pinar H Kodaman, Hugh S Taylor
Dec 2, 2014·Neuroscience and Biobehavioral Reviews·L A BarrosM L Andersen
Oct 6, 2005·Respiratory Physiology & Neurobiology·J Soliz, V Joseph
Nov 26, 2016·Nature Reviews. Cancer·Jason S CarrollWayne D Tilley
Jul 12, 2018·Endocrine-related Cancer·Caroline A LambClaudia Lanari
Feb 6, 2004·Breast Cancer Research and Treatment·E M McGowanC L Clarke
Feb 13, 2008·The American Journal of Clinical Nutrition·Fei Xue, Karin B Michels
Feb 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·W L KrausB S Katzenellenbogen
Jan 31, 2006·Molecular and Cellular Endocrinology·M R YudtZ Zhang

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