Progesterone receptor gene polymorphisms are not associated with preterm birth in a Hispanic population

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Laura Diaz-CuetoFabian Arechavaleta-Velasco

Abstract

To determine whether increased frequency of mutant alleles of the progesterone receptor gene (PGR) was associated with preterm birth in a population of Hispanic women. Placental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by polymerase chain reaction (PCR) restriction fragment length polymorphism. The chi(2) test and t test were used to calculate statistical significance. Linkage disequilibrium was calculated using the Linkage Disequilibrium Analyzer program. The genotypic frequencies of the 4 polymorphisms were not significantly different between the study and control groups. In addition, there was complete linkage disequilibrium between V660L, H770H, and PROGINS polymorphisms, but not with +331G/A polymorphism. The present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population.

References

Nov 16, 1993·Biochimica Et Biophysica Acta·M MisrahiE Milgrom
Jul 13, 2000·The New England Journal of Medicine·N A Holtzman, T M Marteau
Feb 24, 2001·The New England Journal of Medicine·J G Sotos, H Y Rienhoff
Oct 12, 2001·Annals of the New York Academy of Sciences·J R ChallisN Alfaidy
Oct 26, 2001·Journal of the Society for Gynecologic Investigation·C KurzL A Hefler
Apr 6, 2002·Mutation Research·C J DonaldsonM A Batzer
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Immaculata De VivoDavid J Hunter
Nov 6, 2002·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·W Gibb, J R G Challis
Jun 13, 2003·The New England Journal of Medicine·Paul J MeisUNKNOWN National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Daniel W CramerImmaculata De Vivo
Nov 5, 2003·Bioinformatics·Keyue DingYan Shen
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Irina U AgoulnikDirk G Kieback
Feb 5, 2005·Seminars in Fetal & Neonatal Medicine·Shi Wu WenMark Walker
Dec 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna K Sfakianaki, Errol R Norwitz
Jan 6, 2007·Seminars in Reproductive Medicine·Sam Mesiano
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Tamas Zakar, Frank Hertelendy

❮ Previous
Next ❯

Citations

Feb 12, 2010·The New England Journal of Medicine·Louis J Muglia, Michael Katz
May 24, 2011·American Journal of Obstetrics and Gynecology·Tracy A ManuckSusan M Ramin
Oct 22, 2016·BMC Genomics·Ishfaq A SheikhMohammed Al-Qahtani
Jul 19, 2017·Reproductive Sciences·Bruna Ribeiro de Andrade Ramos, Márcia Guimarães da Silva
Jan 5, 2021·Human Genomics·Manci LiPeter A Larsen
Dec 19, 2017·American Journal of Obstetrics and Gynecology·Jerome F StraussHarvey A Schenkein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.