PROGESTERONE RECEPTOR GENE POLYMORPHISMS AS GENETIC RISK FACTOR OF THREATENED ABORTION

Fiziolohichnyĭ zhurnal
O S Kryvopustor, V E Dosenko

Abstract

Determination of the progesterone receptor gene polymor- phisms rs590688 C/G and rs500760 A/G was provided using PCR method. To investigate the genetical precursors of threatened abortion the next groups were included: 67 patients with threatened abortion and 93 healthy persons. These allelic variants have the significantly different at rs590688 study: C/C - 23,9%, C/G - 44,8%, GIG - 31,3%, and C/C - 27,2%, C/G - 58,7%, GIG - 14,1% in the control group (P<0,05 by x2-test). The allelic variants of the rs500760 polymorphism did not differ statistically in the study group A/A 53,7%, A/G - 40,3%, GIG - 6% in the control group A/A- 52,2%, A/G - 44,6%, GIG - 3,3% (P>0,05 by x2-test). Distribution of minor homozygote GIG polymorphism rs590688 progesterone receptor gene in patients with threatened abortion in our study almost in 10 times higher in comparing with women of Taiwanese Han population, who had idiopathic recurrent pregnancy loss. The obtained data indicate significant ethnic differences in PGR and show polymorphism rs590688 clinical significance.

References

Sep 1, 1996·British Journal of Obstetrics and Gynaecology·T Farrell, P Owen
Mar 24, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Andreas SchweikertLudwig Wildt
Aug 9, 2006·American Journal of Obstetrics and Gynecology·Alyssa A MillsAmy P Murtha
Dec 1, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·L SaraswatS Bhattacharya
Mar 3, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G BardaJ Bar
Nov 19, 2010·Journal of Assisted Reproduction and Genetics·Mei-Tsz SuPao-Lin Kuo
May 24, 2011·American Journal of Obstetrics and Gynecology·Tracy A ManuckSusan M Ramin
Sep 26, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M O'Brien

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