Progesterone receptor in Norplant endometrium

Human Reproduction
T M LauP A Rogers

Abstract

Endometrial progesterone receptor plays an important role in determining the biological activity of progestogens in fertility regulation. Studies during the normal menstrual cycle have shown that the concentrations of endometrial progesterone receptor and its mRNA vary in glandular epithelia but remain steady in stromal cells. There is general agreement between progesterone receptor mRNA and protein levels during the normal menstrual cycle. Norplant endometrium had an increase in immunoreactive progesterone receptor concentration but a reduction in progesterone receptor mRNA levels compared with controls. An immunohistochemical study, using the expression of the lysosomal protease cathepsin D as a marker for the functional status of progesterone receptors, failed to confirm the functionality of the receptors in Norplant endometrium. Together, these results suggest that (i) there is a differential sensitivity of glandular and stromal progesterone receptors to steroid regulation during the normal menstrual cycle; (ii) there appears to be a dissociation between the concentrations of progesterone receptor and its mRNA in Norplant endometrium; and (iii) there was significantly more progesterone receptor mRNA and lower plasma oestrog...Continue Reading

Citations

Sep 10, 2020·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Feb 17, 2018·American Journal of Reproductive Immunology : AJRI·Stamatios PetousisDavid Rousso
Oct 11, 2012·Animal Reproduction Science·F De AmicisS Aquila

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