Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor

Neuroendocrinology
Samaneh YazdaniH Sasano

Abstract

Pancreatic neuroendocrine tumors (PNETs) have been reported to express progesterone receptor (PR), and its expression has been demonstrated to be a favorable prognostic factor in these patients. We examined the status of the PR isoforms PRA and PRB in the human PNET cell line and their association with cell proliferation of the tumor cells, which is closely related to the clinical outcome of PNET patients. Quantitative RT-PCR and cell proliferation assays were performed following treatment with progesterone and RU-486 as a PR antagonist in nontransfected and PRA-transfected cells of the NET cell line QGP-1, which expresses PRB in its native state. PRA, PRB and cyclin D1 (CCND1) were immunolocalized in 87 PNET cases, and the results were compared with clinicopathological parameters. CCND1, c-Fos and c-Jun mRNA levels were all significantly increased by treatment with progesterone in QGP-1 cells with PRB expression compared with PRA-transfected cells (p = 0.02, p = 0.007 and p = 0.001, respectively). The proliferative activity of QGP-1 cells with PRB expression was also significantly stimulated by the administration of progesterone (p = 0.008). PRA immunoreactivity was significantly decreased in higher-grade PNETs (p = 0.04), whe...Continue Reading

Citations

Jun 28, 2016·Human Pathology·Abdullah AzmahaniHironobu Sasano
Dec 5, 2017·Reviews in Endocrine & Metabolic Disorders·Krystallenia AlexandrakiGregory Kaltsas
Apr 18, 2019·Minerva endocrinologica·Krystallenia I AlexandrakiGregory A Kaltsas
Jun 17, 2020·Frontiers in Oncology·Martine BocchiniMassimiliano Mazza
Oct 29, 2019·Neuroendocrinology·Alison May BernerChristina Thirlwell

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