Progesterone receptor isoforms expression pattern in human astrocytomas

Brain Research Bulletin
Gabriela González-AgüeroIgnacio Camacho-Arroyo

Abstract

Progesterone receptors (PR) have been detected in human astrocytomas; however, the expression pattern of PR isoforms in these brain tumors is unknown. Progesterone receptor isoforms expression was studied in 13 biopsies of astrocytomas (6 grade III, and 7 grade IV) from adult Mexican patients by using reverse transcription-polymerase chain reaction and immunohistochemistry. Progesterone receptor expression was observed at mRNA and at protein levels in 66% and 83% of astrocytomas grade III, respectively, whereas 100% of astrocytomas grade IV expressed PR. Almost all PR mRNA content in astrocytomas grades III and IV corresponded to PR-B. The number of immunoreactive cells expressing PR-B was higher than that expressing PR-A in 73% of the cases. Estrogen receptor-alpha protein was only observed in 33% of astrocytomas grade III, whereas no astrocytomas grade IV expressed it. These data suggest that PR-B is the predominant isoform expressed in human astrocytomas grades III and IV, and that estrogen receptor-alpha is not expressed in astrocytomas grade IV.

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Citations

Nov 17, 2007·Endocrine·Gabriela González-AgüeroIgnacio Camacho-Arroyo
Oct 22, 2010·Endocrine·Olivia Tania Hernández-HernándezIgnacio Camacho-Arroyo
Jun 14, 2005·Archives of Medical Research·Ivone CastroArturo Barrón
Sep 8, 2009·Journal of Neurosurgery·Sudhakar VadiveluMichael Schulder
Jul 2, 2014·BioMed Research International·Liliana Germán-CastelánIgnacio Camacho-Arroyo
Apr 5, 2014·Journal of Neuro-oncology·Gabriella M AnicKathleen M Egan
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Nov 23, 2011·British Journal of Neurosurgery·Raghu RamaswamyTimothy Dawson
May 1, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Olivia Tania Hernández-HernándezIgnacio Camacho-Arroyo
Dec 20, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Edith Cabrera-MuñozIgnacio Camacho-Arroyo
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Jul 4, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ignacio Camacho-ArroyoGenoveva González-Morán
Aug 16, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Paulina Valadez-CosmesIgnacio Camacho-Arroyo
Jul 3, 2016·Molecular and Cellular Endocrinology·Paulina Valadez-CosmesIgnacio Camacho-Arroyo
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Mar 24, 2021·Biology of Sex Differences·Claudia Bello-Alvarez, Ignacio Camacho-Arroyo
Jun 26, 2021·OncoTargets and Therapy·Denisse Arcos-MontoyaAliesha González-Arenas

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