Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis.

Journal of Cellular and Molecular Medicine
Hsun-Yu HuangHong-Lin Chan

Abstract

Cancer metastasis is a common cause of failure in cancer therapy. However, over 60% of oral cancer patients present with advanced stage disease, and the five-year survival rates of these patients decrease from 72.6% to 20% as the stage becomes more advanced. In order to manage oral cancer, identification of metastasis biomarker and mechanism is critical. In this study, we use a pair of oral squamous cell carcinoma lines, OC3, and invasive OC3-I5 as a model system to examine invasive mechanism and to identify potential therapeutic targets. We used two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) to examine the global protein expression changes between OC3 and invasive OC3-I5. A proteomic study reveals that invasive properties alter the expression of 101 proteins in OC3-I5 cells comparing to OC3 cells. Further studies have used RNA interference technique to monitor the influence of progesterone receptor membrane component 1 (PGRMC1) protein in invasion and evaluate their potency in regulating invasion and the mechanism it involved. The results demonstrated that expression of epithelial-mesenchymal transition (EMT) markers...Continue Reading

References

Jun 2, 2004·International Journal of Cancer. Journal International Du Cancer·Giles C WarnerSuzanne Kamel-Reid
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·André Lopes CarvalhoLuiz Paulo Kowalski
Feb 24, 2006·Nature Reviews. Cancer·Meyling H Cheok, William E Evans
Oct 4, 2006·Oncology Reports·Yoshikuni KatoHideki Tanzawa
Dec 13, 2006·Cancer Metastasis Reviews·Wen-Sheng Wu
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Martin KlemkeYvonne Samstag
Jun 23, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Michael A Cahill
Nov 6, 2007·Biochimica Et Biophysica Acta·Xiaohong LiPatricia D Wilson
Mar 6, 2008·The Journal of Clinical Endocrinology and Metabolism·John J PelusoKathryn Phoenix
Feb 11, 2010·Molecular and Cellular Endocrinology·J J PelusoC A Wu
Feb 19, 2010·The Journal of Pharmacology and Experimental Therapeutics·Ikhlas S AhmedRolf J Craven
Oct 20, 2010·International Journal of Molecular Sciences·Martha E Arellano-GarciaShen Hu
Jan 12, 2011·Biochemical and Biophysical Research Communications·Yuri SaitoYuzuru Kanakura
May 6, 2011·Molecular & Cellular Proteomics : MCP·Charity T AikenLan Huang
Aug 10, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shingo OdaTsuyoshi Yokoi
Oct 18, 2011·Cell·Scott Valastyan, Robert A Weinberg
Jun 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan LuXuemei Wang
Oct 15, 2013·Immunological Reviews·Sharon Celeste Morley
Mar 4, 2014·Cellular Signalling·Monira HoqueThomas Grewal
Mar 10, 2016·Oncotarget·Shun-Hong HuangPing-Chiang Lyu

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Citations

Apr 10, 2021·Cell Communication and Signaling : CCS·Sang R LeeEui-Ju Hong

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Methods Mentioned

BETA
transfection
transfect
protein folding
ELISA
flow cytometry

Software Mentioned

Zeiss Axiovision
DeCyder
Cflow Plus
Adobe Photoshop
Axio Vision

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