Progesterone Receptor Signaling in Uterine Myometrial Physiology and Preterm Birth

Current Topics in Developmental Biology
San-Pin Wu, Francesco J DeMayo

Abstract

Myometrium holds the structural integrity for the uterus and generates force for parturition with its primary component, the smooth muscle cells. The progesterone receptor mediates progesterone-dependent signaling and connects to a network of pathways for regulation of contractility and inflammatory responses in myometrium. Dysfunctional progesterone signaling has been linked to pregnancy complications including preterm birth. In the present review, we summarize recent findings on modifiers and effectors of the progesterone receptor signaling. Discussions include novel conceptual discoveries and new development in legacy pathways such as the signal transducers NF-κB, ZEB, microRNA, and the unfolded protein response pathways. We also discuss the impact of progesterone receptor isoform composition and ligand accessibility in modification of the progesterone receptor genomic actions.

Citations

Mar 17, 2018·Biology of Reproduction·Lan HaiJohn P Lydon
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·San-Pin WuFrancesco J DeMayo
Mar 5, 2020·Journal of Neuroscience Research·Alexandra M YawHanne M Hoffmann
Jun 24, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sathya Krishnasamy, Thomas L Abell
Aug 21, 2020·Reproductive Sciences·Damian D GuerraK Joseph Hurt
Apr 16, 2019·Frontiers in Endocrinology·Nishel M ShahMark R Johnson
May 1, 2018·Trends in Endocrinology and Metabolism : TEM·San-Pin WuFrancesco J DeMayo

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