Progesterone-Regulated Endometrial Factors Controlling Implantation

American Journal of Reproductive Immunology : AJRI
Arpita S BhurkeMilan K Bagchi

Abstract

The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. In recent years, chromatin immunoprecipitation-sequencing in combination with microarray-based gene expression profiling analyses have revealed that the PR isoforms control a substantially large cistrome and transcriptome during endometrial differentiation in the human and the mouse. Genetically engineered mouse models have established that several PR-regulated genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization. PR-A and PR-B also collaborate with other transcription factors, such as FOS, JUN, C/EBPβ and STAT3, to regulate the expression of many target genes that functions in concert to properly control uterine epithelial proliferation, stromal differentiation, angiogenesis, and local immune response to render the uterus 'receptive' and allow embryo implantation. This review article highlights recent work describing the key PR-regulated pathways that govern critical uterine functions during establishment of pregnancy.

References

Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Jan 1, 1995·Annual Review of Medicine·R C RibeiroJ D Baxter
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Apr 29, 1998·The Journal of Clinical Investigation·H S TaylorP Igarashi
Aug 24, 1999·Methods : a Companion to Methods in Enzymology·B K Tye
Jul 7, 2000·Developmental Biology·D D CarsonK Yoshinaga
Jun 23, 2001·Molecular and Cellular Endocrinology·O M ConneelyF J De Mayo
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G ChengC L Stewart
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Magali AncelinMartine Perrot-Applanat
May 8, 2002·The Journal of Clinical Investigation·David E Levy, Chien-kuo Lee
Sep 28, 2002·Molecular Endocrinology·Norio TakamotoFrancesco J DeMayo
Jun 8, 2004·Endocrine Reviews·S K DeyHaibin Wang
Jan 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Srinivasa Raju MantenaMilan K Bagchi
May 9, 2006·Cell·David M Lonard, Bert W O'Malley
Sep 5, 2006·Nature Genetics·Kevin LeeFrancesco J DeMayo
Feb 10, 2007·International Immunology·Cherie L ButtsEsther M Sternberg
May 23, 2007·Molecular and Cellular Biology·Kevin Y LeeFrancesco J DeMayo
Feb 2, 2008·The Journal of Reproduction and Development·Shoichi WakitaniYasuo Kiso
Nov 27, 2008·The Journal of Clinical Investigation·Vicki PlaksSteffen Jung
Nov 29, 2008·Molecular Human Reproduction·C GaneffR Winkler
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jae-Wook JeongFrancesco J DeMayo
May 21, 2009·Journal of Anatomy·Harmeet Singh, John D Aplin
Jan 28, 2010·Seminars in Reproductive Medicine·Cyril Y RamathalMilan K Bagchi
Dec 18, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heather L FrancoFrancesco J DeMayo
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Fuller W BazerRobert C Burghardt
Apr 30, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·D V Huyen, B M Bany
Jun 7, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Antonina I Frolova, Kelle H Moley
Dec 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heather L FrancoFrancesco J Demayo
Apr 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sanhita Ray, Jeffrey W Pollard

❮ Previous
Next ❯

Citations

Jun 12, 2016·Seminars in Immunopathology·Mayumi MoriJúlia Szekeres-Bartho
Feb 27, 2017·Journal of Biochemical and Molecular Toxicology·Pablo Dominguez-LopezFabian Arechavaleta-Velasco
Mar 15, 2018·The Journal of Endocrinology·Min HuHåkan Billig
Jan 19, 2018·Biology of Reproduction·Gregory W BurnsThomas E Spencer
Dec 27, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S Gaggiotti-MarreB Coroleu
Feb 26, 2019·American Journal of Reproductive Immunology : AJRI·Biserka Mulac-JeričevićJulia Szekeres-Bartho
Nov 13, 2018·Reproduction, Fertility, and Development·Jane C Fenelon, Bruce D Murphy
Jan 11, 2018·Endocrinology·Nancy AsharyDeepak Modi
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·San-Pin WuFrancesco J DeMayo
Mar 5, 2020·Journal of Neuroscience Research·Alexandra M YawHanne M Hoffmann
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Ru-Pin Alicia ChiFrancesco DeMayo
Feb 8, 2020·Physiological Reviews·Hilary O D CritchleyAlistair R W Williams
Nov 14, 2019·BMC Genomics·Jennifer N KiserHolly L Neibergs
May 5, 2020·Endocrine Reviews·Md Soriful IslamJames Segars
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Andrew M KelleherThomas E Spencer
Jul 4, 2018·Journal of Assisted Reproduction and Genetics·Saniya LaheriDeepak Modi
Aug 24, 2018·International Journal of Molecular Sciences·Sofia MakievaPaola Viganò
Jul 18, 2018·Reproductive Medicine and Biology·Hidetaka OkadaHiromi Murata
Oct 30, 2019·Balsaeng'gwa saengsig·Tae Hoon Kim, Jae-Wook Jeong
Nov 18, 2020·Journal of Cellular and Molecular Medicine·Yao XiongYuanzhen Zhang
Apr 24, 2021·Human Reproduction·Khaleque N KhanJo Kitawaki
May 22, 2020·Molecular and Cellular Endocrinology·M M MilesiJ Varayoud
May 7, 2021·The Journal of Clinical Endocrinology and Metabolism·Stefania SalsanoFrancisco Domínguez
Jun 10, 2021·Biology of Reproduction·Kailiang LiRomana A Nowak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.