Progesterone regulates secretin expression in mouse uterus during early pregnancy

Reproductive Sciences
Zhu HuangZeng-Ming Yang

Abstract

Secretin, a classical gastrointestinal and neuroendocrine peptide, plays an important role in maintaining the body fluid balance. However, the expression and regulation of secretin in the reproductive system are still unknown. In our study, secretin is specifically expressed in the decidua on days 5 to 8 of pregnancy. Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization. Progesterone induces secretin expression in ovariectomized mice and cultured stromal cells, which is abrogated by specific LY294002. Because secretin is mainly localized in the decidua and also strongly expressed during in vitro decidualization, secretin may play a role during mouse decidualization through regulating cyclic adenosine monophosphate level.

References

May 1, 1975·Journal of Reproduction and Fertility·P V Holmes, S Bergström
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·J M Davison, M D Lindheimer
Apr 1, 1989·British Journal of Obstetrics and Gynaecology·N HolstJ M Maltau
Jul 1, 1974·Journal of Reproduction and Fertility·F LeroyD Brasseur
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Oct 24, 2002·Molecular Neurobiology·Samuel S M NgBilly K C Chow
Jun 8, 2004·Endocrine Reviews·S K DeyHaibin Wang
Jan 22, 2005·Gene Expression Patterns : GEP·Francis K Y SiuBilly K C Chow
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
Mar 8, 2006·Experimental & Molecular Medicine·Hyeon Soo KimPann-Ghill Suh
Jul 18, 2006·Biochimica Et Biophysica Acta·Fuminori UmenishiRobert W Schrier
Aug 5, 2006·Annals of the New York Academy of Sciences·J Y S ChuB K C Chow
Aug 5, 2006·Annals of the New York Academy of Sciences·J Y S ChuB K C Chow
Aug 5, 2006·Annals of the New York Academy of Sciences·Francis K Y SiuBilly K C Chow
Sep 30, 2006·Human Molecular Genetics·Ichiko NishijimaAllan Bradley
Nov 13, 2007·Cellular Signalling·William A Sands, Timothy M Palmer
Jun 7, 2008·Neuroscience·T YamagataI Nishijima
Jun 17, 2008·The Journal of Biological Chemistry·Shi-Jun HuZeng-Ming Yang
Jun 27, 2008·Endocrine Journal·Tetsuo Maruyama, Yasunori Yoshimura
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jessica Y S ChuBilly K C Chow
Aug 27, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vien H Y LeeBilly K C Chow
Oct 15, 2010·Kidney International·Jessica Y S ChuBilly K C Chow
Jan 21, 2011·Biology of Reproduction·Griselda VallejoPatricia Saragüeta
Aug 20, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria Dolors SansJohn A Williams

❮ Previous
Next ❯

Citations

Aug 6, 2020·Reproductive Sciences·Parnian Kheirkhah RahimabadWilfried Karmaus

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved