Progesterone resistance in a baboon model of endometriosis

Seminars in Reproductive Medicine
A T Fazleabas

Abstract

The development of a baboon model of induced endometriosis, which recapitulates the retrograde menstruation hypothesis, has greatly facilitated our understanding of the early events associated with the disease process. Sequential analysis of the eutopic endometrium following the establishment of disease suggests that the development of progesterone resistance is a gradual process and becomes evident after 6 months of disease induction. This resistance is manifested by a decreased responsiveness of the progesterone receptor and its chaperone immunophilins as well as epigenetic modifications of progesterone-regulated genes. In comparative studies, the time-dependent changes observed in the baboon eutopic endometrium are similar to those that have been reported to be altered in women with endometriosis. The baboon model therefore provides insight into the potential mechanisms by which genes in the eutopic endometrium are dysregulated and how this alteration results in infertility that is associated with endometriosis.

Citations

Feb 23, 2013·Archives of Gynecology and Obstetrics·Arif Kokcu
Oct 28, 1997·Fertility and Sterility·T M D'Hooghe
Mar 30, 2013·Human Reproduction Update·Fernando M ReisRobert N Taylor
Jan 11, 2013·Biology of Reproduction·Ov D Slayden
May 4, 2010·Clinical Obstetrics and Gynecology·Breton F Barrier
Mar 2, 2012·Reproductive Sciences·Beth J PlanteSteven L Young
Aug 13, 2010·The Journal of Clinical Endocrinology and Metabolism·Mary Ellen PavoneYou-Hong Cheng
Sep 16, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·A G BraundmeierR A Nowak
Mar 19, 2014·Human Reproduction Update·Sang Jun Han, Bert W O'Malley
Sep 5, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi KobayashiHiroshi Shigetomi
Oct 9, 2015·Women's Health·Bulent Haydardedeoglu, Hulusi Bulent Zeyneloglu
Jul 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Joe A AroshSakhila K Banu
May 12, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivo Brosens, Giuseppe Benagiano
Aug 21, 2012·Gynécologie, obstétrique & fertilité·S Colette, J Donnez
Feb 15, 2012·Autoimmunity Reviews·Vered H EisenbergDavid Soriano
Nov 17, 2011·Molecular and Cellular Endocrinology·Marwa Al-SabbaghJan J Brosens
Jun 7, 2011·Fertility and Sterility·Kathryn SmithLynnette K Nieman
Jun 24, 2017·Biology of Reproduction·Hugh S TaylorAntoni J Duleba
Jan 21, 2018·Scientific Reports·N Schlabritz-LoutsevitchE J Dick
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Sep 1, 2013·Expert Review of Endocrinology & Metabolism·Jerome H Check, Rachael Cohen
Jul 22, 2018·Nature Reviews. Disease Primers·Krina T ZondervanPaola Viganò
Aug 14, 2020·Journal of Translational Medicine·Helena MalvezziCarla de Azevedo Piccinato
May 22, 2018·International Journal of Genomics·Jiaxing HeTianmin Xu
Oct 27, 2020·Seminars in Reproductive Medicine·Ryan M MarquardtAsgerally T Fazleabas
May 8, 2021·Frontiers in Cell and Developmental Biology·Ruben HeremansHugo Vankelecom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved