Progesterone resistance in women who have had breast cancer

British Journal of Obstetrics and Gynaecology
H W SimpsonG H Beastall

Abstract

To investigate whether certain physiological responses to luteal progesterone are normal in women previously treated for breast cancer. Salivary progesterone concentrations, basal body temperatures, and breast blood flow changes (surface temperature method) were all recorded daily for one natural menstrual cycle. Participants in the study made saliva collections and temperature measurements at home under semi-standardised conditions with supervisory visits by a project nurse. Twenty-five controls were compared with 30 women with previous breast cancer; all but three participants were parous and the average ages were 39 years (range 28-48) and 40 years (range 29-46), respectively. On average the women with previous breast cancer had had surgery 2.4 years previously; the operation was usually mastectomy, leaving the contralateral breast for study. Follicular phase (day 1-14) oral temperature averages were statistically indistinguishable between women in the control group and those with previous breast cancer. Luteal progesterone profiles were considered in the normal range for the controls and patients. However, the women with previous breast cancer, on average, exhibited a significantly smaller rise in the luteal phase basal bod...Continue Reading

References

May 1, 1987·AJR. American Journal of Roentgenology·T B Hunter
Mar 8, 1985·Science·J G Cannon, C A Dinarello
Jan 1, 1985·Breast Cancer Research and Treatment·D Y Wang, I S Fentiman
May 1, 1985·American Journal of Epidemiology·T ByersJ Marshall
Jan 1, 1985·European Journal of Cancer & Clinical Oncology·G F ReadK Griffiths
Oct 15, 1974·American Journal of Obstetrics and Gynecology·K J Zuspan, F P Zuspan
Aug 1, 1972·American Journal of Obstetrics and Gynecology·E D JohanssonC Gemzell
May 1, 1972·The Science of the Total Environment·E I HamiltonJ J Cleary
Aug 1, 1981·American Journal of Epidemiology·L D CowanG S Jones
Dec 1, 1981·Fertility and Sterility·J E Bauman
Sep 1, 1993·Breast Cancer Research and Treatment·H W SimpsonA Turkes
Apr 1, 1993·Nihon rinsho. Japanese journal of clinical medicine·E Takeda, I Yokota
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H W SimpsonK Griffiths
Jun 1, 1953·The Journal of Obstetrics and Gynaecology of the British Empire·V R PICKLES
May 1, 1992·Trends in Endocrinology and Metabolism : TEM·N G Seidah, M Chrétien

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Citations

Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·M I NewB O'Malley
Oct 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Tae Hoon KimBruce A Lessey
Dec 2, 2021·Human Reproduction·Philippe R KoninckxDan C Martin

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