PMID: 11925385Apr 2, 2002Paper

Progesterone serum levels during the follicular phase of the menstrual cycle originate from the crosstalk between the ovaries and the adrenal cortex

Human Reproduction
Christian De GeyterWolfgang Holzgreve

Abstract

The preovulatory rise of progesterone is important for ovulation, but both its regulation and its origin are controversial. Three experiments were performed to determine whether follicular phase progesterone arises from the ovary, the adrenal cortex or both. The first study was performed in patients scheduled for assisted reproduction, who received a long-acting GnRH agonist either during intake of an oral contraceptive or during the luteal phase of an otherwise untreated menstrual cycle. The second study was also performed during down-regulation with a GnRH agonist: some patients with elevated progesterone levels received dexamethasone (DXM). Others with similarly elevated basal progesterone levels and those with low progesterone levels were not treated with DXM and served as controls. Finally, adrenocorticotrophic hormone (ACTH) tests were performed in normocyclic volunteers both during early and late follicular phase and during intake of a contraceptive pill. During the suppression of endogenous gonadotrophin secretion progesterone levels rose after the administration of ACTH, but not of GnRH. DXM did not prevent the preovulatory rise of the serum progesterone concentration. The ACTH-stimulated concentration of progesterone ...Continue Reading

Citations

Feb 26, 2013·Ultrasound Quarterly·Fernando Bonilla-MusolesFrancisco Bonilla
Jun 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumSlavko Oreškovic
May 17, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Christian De GeyterMaria De Geyter
May 21, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumLidija Beketić-Orešković
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Sep 6, 2011·Psychoneuroendocrinology·Susan S GirdlerA Leslie Morrow
Feb 9, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mamiko KoshibaShun Nakamura
Dec 15, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Suhail A R DoiKamal A S Al-Shoumer
Jun 30, 2006·Fertility and Sterility·Virginia J VitzthumBrady West
Apr 29, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Josep MarcosOscar J Pozo
Sep 4, 2016·Human Reproduction·Jurate AleknaviciuteSteven A Kushner
Jun 4, 2005·Human Reproduction·Suhail A R DoiKamal A S Al-Shoumer
Nov 26, 2008·The Journal of Biological Chemistry·Linda J MullinsChristopher J Kenyon
Jul 28, 2018·Journal of Assisted Reproduction and Genetics·Apostolos KaponisGeorge Decavalas
Jan 25, 2020·Seminars in Reproductive Medicine·Gurkan BozdagHakan Yarali
Oct 21, 2020·Reproduction in Domestic Animals = Zuchthygiene·Alessandro TroisiJohn Paul Verstegen

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