Progesterone synthesis in the nervous system: implications for myelination and myelin repair.

Frontiers in Neuroscience
Michael SchumacherAbdel M Ghoumari

Abstract

Progesterone is well known as a female reproductive hormone and in particular for its role in uterine receptivity, implantation, and the maintenance of pregnancy. However, neuroendocrine research over the past decades has established that progesterone has multiple functions beyond reproduction. Within the nervous system, its neuromodulatory and neuroprotective effects are much studied. Although progesterone has been shown to also promote myelin repair, its influence and that of other steroids on myelination and remyelination is relatively neglected. Reasons for this are that hormonal influences are still not considered as a central problem by most myelin biologists, and that neuroendocrinologists are not sufficiently concerned with the importance of myelin in neuron functions and viability. The effects of progesterone in the nervous system involve a variety of signaling mechanisms. The identification of the classical intracellular progesterone receptors as therapeutic targets for myelin repair suggests new health benefits for synthetic progestins, specifically designed for contraceptive use and hormone replacement therapies. There are also major advantages to use natural progesterone in neuroprotective and myelin repair strateg...Continue Reading

Citations

Sep 10, 2013·Progress in Neurobiology·Paula J BruntonJonathan J Hirst
Oct 15, 2013·Progress in Neurobiology·Roberto Cosimo Melcangi, Gian Carlo Panzica
May 9, 2014·Journal of Chemical Neuroanatomy·Emi KiyokageKazunori Ishimura
Oct 16, 2014·Neural Regeneration Research·Florencia Labombarda, Daniel Garcia-Ovejero
Aug 12, 2014·Current Neurology and Neuroscience Reports·Meredith D HartleyDennis Bourdette
Jul 17, 2013·Climacteric : the Journal of the International Menopause Society·N PluchinoA R Genazzani
Dec 5, 2015·Frontiers in Psychiatry·Valeria Hansberg-PastorIgnacio Camacho-Arroyo
Nov 26, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Michael SchumacherRachida Guennoun
Apr 1, 2015·Steroids·Silvia GiattiRoberto C Melcangi
Nov 26, 2015·Neural Regeneration Research·Stephen Y Cheng, Gilberto K K Leung
Aug 16, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Paulina Valadez-CosmesIgnacio Camacho-Arroyo
Apr 7, 2016·Progress in Neurobiology·Bruno Dutra ArboMaria Flavia Ribeiro
Nov 6, 2012·Neurobiology of Aging·Donatella CarusoRoberto C Melcangi
Dec 12, 2012·European Journal of Pharmacology·Javad VerdiHamid Reza Banafshe
Apr 1, 2014·American Journal of Human Genetics·Thomas PrukopMichael W Sereda
Dec 3, 2014·Fitoterapia·Jing-Yang Zhang, Yong-Xiang Wang
Sep 13, 2016·Molecular and Cellular Endocrinology·Renate Louw-du ToitDonita Africander
Sep 24, 2016·Molecular Neurobiology·Samah Kalakh, Abdeslam Mouihate
Jun 17, 2016·Journal of Neuroendocrinology·M F RossettiR Cabrera
Jul 8, 2017·The Journal of Comparative Neurology·Lisa M DiCarloRichard S Nowakowski
Jan 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Miguel Ortíz-RenteríaSara L Morales-Lázaro
Feb 27, 2013·Nature Reviews. Endocrinology·Roberta D Brinton
Jun 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G P IvanovaL M Vasilenko
Dec 21, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Adrian J LloydI Nicol Ferrier
Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verena Theis, Carsten Theiss

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
contraception
hormone replacement therapy
sedation

Software Mentioned

Popart

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2022 Meta ULC. All rights reserved