Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors

Psychopharmacology
Cheryl A FryeMadeline E Rhodes

Abstract

Aging is associated with reduced secretion of, and down-regulation of receptors for, progesterone (P); yet, P's effects when administered to younger and older animals have not been systematically investigated. Some of P's antianxiety effects may be due to its conversion to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) and its subsequent actions as a positive modulator at GABAA receptor complexes (GBRs). We investigated whether P administration can decrease anxiety behavior of progestin receptor (PR) knockout (PRKO) or wild-type control mice. P (10 mg/kg) or vehicle (propylene glycol) were administered subcutaneously to intact, female or male wild-type or PRKO mice that were either 9-12 or 18-24 months of age. Behavior in tasks that assess spontaneous activity (activity monitor and roto-rod), free exploration of a novel environment (open field, elevated plus maze, and elevated zero maze), and conflict behavior (mirror chamber, dark-light transition, and punished drinking) were examined 1 h after injection. P significantly decreased anxiety behavior of both PRKO and wild-type mice. P did not alter motor behavior but increased central entries in the open field, time in the open quadrants of the elevated zero maze, time ...Continue Reading

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Citations

Oct 20, 2012·Journal of Proteome Research·Ze-Ping HuEric Chun Yong Chan
Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cheryl A FryeKanako Sumida
Oct 30, 2008·PloS One·Catherine J Auger, Robin M Forbes-Lorman
Mar 7, 2014·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
Sep 29, 2011·Behavioural Brain Research·Carolyn J KoonceCheryl A Frye
Jan 23, 2010·Behavioural Brain Research·Cheryl A Frye, Ichiro Sora
Oct 7, 2009·Physiology & Behavior·Alicia A Walf, Cheryl A Frye
May 12, 2009·Hormones and Behavior·Matthew J FuxjagerCatherine A Marler
Apr 29, 2008·Neuroscience Letters·Cheryl A Frye, Alicia A Walf
Nov 9, 2007·Neurobiology of Learning and Memory·Cheryl A Frye, Alicia A Walf
Aug 30, 2011·Social Issues and Policy Review·Jon K Maner, Douglas T Kenrick
Feb 13, 2010·Journal of Neuroscience Methods·Neil E PatersonTaleen Hanania
Jul 31, 2007·Pharmacology & Therapeutics·Michael SchumacherAlejandro F De Nicola
Apr 8, 2017·Neuroscience Letters·Carlos M Contreras, Ana G Gutiérrez-García
Jun 22, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G P IvanovaL M Vasilenko
Mar 10, 2017·Women & Health·Mónica Flores-RamosMargus Salinas
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye
Oct 13, 2009·Hormones and Behavior·Marilyn E Carroll, Justin J Anker

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