PMID: 702276Oct 1, 1978Paper

Progestin permeation through polymer membranes I: diffusion studies on plasma-soaked membranes

Journal of Pharmaceutical Sciences
G M ZentnerS W Kim

Abstract

The potential of several commercially available polymeric materials for use in controlled-release drug delivery devices was investigated. Progesterone was used as a model hydrophobic drug. The progesterone permeation rates through polydimethylsiloxane, two polyether urethanes, a hydroxyethyl methacrylate, a polyether urethan--polydimethylsiloxane blend, and a cellulosic membrane were determined. The permeabilities were obtained on nonsoaked membranes and on membranes soaked in plasma for varying times. The purpose of the plasma soaks was to examine the effects of lipid absorption and degradative processes within the membrane on progesterone permeability. This study identified several polymers that show potential for use in controlled-release drug delivery devices. The plasma treatment studies showed that several polymers may not be acceptable. The plasma soak studies were interpreted in terms of the mechanisms of drug permeation through the membranes.

References

Oct 1, 1978·Journal of Pharmaceutical Sciences·G M ZentnerS W Kim
May 1, 1975·Journal of Biomedical Materials Research·R A Abrahams, S H Ronel
Nov 1, 1974·Journal of Biomedical Materials Research·J W Swanson, J E Lebeau
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L C Craig, H C Chen
Jan 1, 1973·Biomaterials, Medical Devices, and Artificial Organs·D J Lyman, S W Kim
Jan 1, 1974·Journal of Biomedical Materials Research·J DrobníkO Wichterle
Dec 1, 1972·Journal of Pharmaceutical Sciences·R G Stehle, W I Higuchi
Apr 1, 1974·Journal of Pharmaceutical Sciences·G L FlynnT J Roseman
May 1, 1972·Journal of Biomedical Materials Research·W D Meester, A B Swanson
Jan 1, 1972·Journal of Pharmaceutical Sciences·T J Roseman
Sep 1, 1971·Journal of Biomedical Materials Research·C K ColtonP C Farrell
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Jan 1, 1971·Journal of Biomedical Materials Research·B K FritzingerD J Lyman
Jan 1, 1966·Endocrinology·P J Dziuk, B Cook

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Citations

Feb 1, 1990·Journal of Clinical Pharmacology·V V Ranade
Jun 20, 1986·Pharmaceutisch Weekblad. Scientific Edition·W E RoordaH E Junginer
Jan 1, 1996·Journal of Microencapsulation·I El-GibalyM O Ahmed
Feb 1, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vaishnavi ChandrasekarBrendan J Casey
Nov 18, 2009·Journal of Polymer Science. Part A, Polymer Chemistry·Jindřich Kopeček

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