Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta

Brain Research
Wilson C J ChungRobert J Handa

Abstract

Perinatal 17beta-estradiol (E2) rapidly and markedly affects the morphological and neurochemical organization of the vertebrate brain. For instance, the sex difference in perinatal progestin receptor (PR) immunoreactivity in the medial preoptic nucleus (MPN) of the rat brain is due to the intracellular conversion of testosterone into E2 in males. Neonatal alpha-fetoprotein prevents circulating estrogens from accessing the brain, therefore, to overcome alpha-fetoprotein sequestration of E2, estrogen replacement studies during development have used natural and synthetic estrogen dosages in the milligram to microgram range. These levels could be considered as supraphysiological. Moreover, it is not clear through which ER subtype E2 acts to induce PR expression in the neonatal rat MPN because E2 binds similarly to estrogen receptor (ER)alpha and ERbeta. Consequently, we investigated whether nanogram levels of E2 affected PR protein and mRNA levels in the neonatal MPN. Furthermore, propylpyrazole-triol (PPT), a highly selective agonist for ERalpha, and diarylpropionitrile (DPN), a highly selective agonist for ERbeta, were used to determine if E2-dependent PR expression in the neonatal rat is mediated through ERalpha and/or ERbeta. I...Continue Reading

References

Dec 1, 1971·Steroids·J P RaynaudE E Baulieu
May 1, 1995·Brain Research. Molecular Brain Research·J A O'KeefeR J Handa
Dec 1, 1994·Hormones and Behavior·J KatoN Yamada-Mouri
Jun 17, 1994·Brain Research. Developmental Brain Research·L L DonCarlos, R J Handa
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J KatoN Mouri
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jul 1, 1996·Neuroscience·G Alvarez-BoladoF J Díez-Guerra
Nov 4, 1998·Frontiers in Neuroendocrinology·B CookeS M Breedlove
Jul 17, 1999·Brain Research. Developmental Brain Research·A E BrownS A Tobet
Jan 11, 2001·Journal of Medicinal Chemistry·S R StaufferJ A Katzenellenbogen
Sep 6, 2001·Hormones and Behavior·D F SwaabT A Ishunina
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chitose OrikasaYasuo Sakuma
Mar 29, 2002·Journal of Neurobiology·Princy S QuadrosChristine K Wagner
May 26, 2004·Brain Research. Developmental Brain Research·Genell D HiltonMargaret M McCarthy
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Alicia A WalfCheryl A Frye
Jul 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Biserka Mulac-Jericevic, Orla M Conneely
Oct 30, 2004·Endocrinology·Trent D LundRobert J Handa
Jan 26, 2005·Journal of Neuroendocrinology·C Orikasa, Y Sakuma

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Citations

Mar 19, 2013·Pflügers Archiv : European journal of physiology·Wilson C J Chung, Anthony P Auger
Nov 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jun Ming WangRoberta Diaz Brinton
Jul 7, 2007·The European Journal of Neuroscience·Brian C TrainorRandy J Nelson
Jan 30, 2009·The European Journal of Neuroscience·Claudia C Aguirre, Michel Baudry

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