PMID: 9441543Jan 1, 1997Paper

Progestins and the endometrium

Zentralblatt für Gynäkologie
A E Schindler

Abstract

Natural progesterone and synthetic progestins lead in the endometrium to the inhibition of mitosis, reduction of estrogens and progesterone receptors and decidualisation of the endometrium. This latter process seems to be of main importance for the implantation. Furtheron, progesterone and progestins induce the formation of IGF-binding proteins (IGFBP's), which for instance lead to the binding of IGF-1 and thereby to a reduction of proliferative or mitogenic effects of the estrogens on the endometrium. In addition, progesterone or progestins induce or inhibit a number of other factors. Among others, protein PP 14 is induced in the endometrium by progesterone or progestins. This protein has immunological properties. While on the one hand the enzyme glutathionperoxydase is blocked, there is on the other hand an induction of transglutamase activity. Furthermore, progestins in high doses lead to a reduction of the microvasculature and a dilatation of the venoles. Therefore, progesterone and progestins are best suited for treatment and prevention of abnormal proliferation of the of the endometrim even up to carcinoma in situ or endometrial cancer. For this, the severity of endometrial changes and the age of the patients have to be t...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.