Progestins oppose the effects of estradiol on the endothelin-1 receptor type B in coronary arteries from ovariectomized hyperlipidemic rabbits

Menopause : the Journal of the North American Menopause Society
Susan H PedersenBent Ottesen

Abstract

Progestins may be associated with the adverse cardiovascular outcomes observed with estrogen plus progestogen therapy, but the mechanism is not resolved. In this study we examined the effect of 17beta-estradiol (E2) alone and in combination with two progestins on the endothelin-1 (ET-1) system in coronary arteries. Watanabe heritable hyperlipidemic rabbits were treated orally with either E2 (4 mg/d), medroxyprogesterone acetate (MPA) (10 mg/d), norethisterone acetate (NETA) (2 mg/d), E2 + MPA, E2 + NETA, or placebo for 16 weeks (n=10 in each group). Coronary arteries were used for mRNA and myograph analyses. E2 alone but not in combination with MPA or NETA increased ETB mRNA expression in coronary arteries. Accordingly, E2 alone but not in combination with MPA or NETA reduced the maximal contraction to ET-1, and the reduction was sustained after ETA but not after ETB blockade. E2 reduced preproendothelin-1 mRNA expression; however, this effect was not blunted by MPA or NETA. ETA and ET-converting enzyme-1 mRNA expression was unaffected by treatment. The data suggest that long-term E2 treatment selectively attenuates ET-1-induced vasoconstriction, possibly by increasing ETB gene expression in rabbit coronary arteries and that th...Continue Reading

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Aug 2, 2017·Megan M. Wenner

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Citations

Feb 10, 2010·Menopause : the Journal of the North American Menopause Society·Olga N LekontsevaSandra T Davidge
Aug 18, 2012·Cardiology Research and Practice·Kento KitadaYasuo Matsumura
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Susan Helene PedersenBent Ottesen
Aug 7, 2012·Journal of Pharmacological Sciences·Mamoru OhkitaYasuo Matsumura
Feb 17, 2018·British Journal of Pharmacology·Margaret A MouatNicola J Smith
Apr 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan M WennerDavid G Edwards
Jul 13, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kelly N SebzdaMegan M Wenner
Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anna E StanhewiczNina S Stachenfeld
Nov 16, 2010·The Journal of Pharmacology and Experimental Therapeutics·Kento KitadaYasuo Matsumura
Jan 8, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Olga LekontsevaSandra T Davidge
Oct 16, 2009·Climacteric : the Journal of the International Menopause Society·A Nath, R Sitruk-Ware
Aug 21, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Leena N ShoemakerMegan M Wenner

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