Progestins to control feline reproduction: Historical abuse of high doses and potentially safe use of low doses

Journal of Feline Medicine and Surgery
Stefano Romagnoli

Abstract

The high fertility rate of cats means that methods to control feline reproduction are a requirement for cat breeders and pet owners, as well as for those involved in the management of feral cat populations. Progestins continue to be used to prevent queens from cycling, and also as an adjunct or alternative to surgical sterilization within trap-neuter-return (TNR) programs. A considerable body of information exists on megestrol acetate (MA) and medroxyprogesterone acetate (MPA), thanks to the many studies and case reports published in the scientific literature over the past 50 years documenting their clinical use in cats. Comparatively less is known about the use in cats of more recent progestins such as levonorgestrel, proligestone, delmadinone, chlormadinone and altrenogest. Based on a combination of dose, frequency and duration of treatment, MA can be categorized into low (0.625 mg/kg/week for up to 30 weeks), medium (0.625 mg/kg q24h for 1 week or q48h for up to 2 weeks) and high (0.625 mg/kg q24h or q48h for several weeks, or weekly for months or years) dosages. Studies suggest that low dosages can be used relatively safely in cats, while higher dosages increase the risk and severity of adverse reactions. Early work showing...Continue Reading

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Citations

Sep 2, 2015·Journal of Feline Medicine and Surgery·Jane K MurrayValerie A W Benka
Mar 5, 2016·Journal of Feline Medicine and Surgery·Gary D Norsworthy
Jan 7, 2016·Journal of Feline Medicine and Surgery·Fiona Hollinshead, Natali Krekeler
Feb 23, 2020·Journal of Feline Medicine and Surgery·Etienne FurthnerAlain Fontbonne
Aug 20, 2020·Journal of Feline Medicine and Surgery·Evelynne Hm de MeloFernando W de Souza
Aug 29, 2019·PloS One·Daniela FerreiraRaquel Chaves

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Methods Mentioned

BETA
contraception

Software Mentioned

FeralStat

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