Progestogen-releasing intrauterine systems for heavy menstrual bleeding.

The Cochrane Database of Systematic Reviews
Magdalena Bofill RodriguezVanessa Jordan


Heavy menstrual bleeding (HMB) impacts the quality of life of otherwise healthy women. The perception of HMB is subjective and management depends upon, among other factors, the severity of the symptoms, a woman's age, her wish to get pregnant, and the presence of other pathologies. Heavy menstrual bleeding was classically defined as greater than or equal to 80 mL of blood loss per menstrual cycle. Currently the definition is based on the woman's perception of excessive bleeding which is affecting her quality of life. The intrauterine device was originally developed as a contraceptive but the addition of progestogens to these devices resulted in a large reduction in menstrual blood loss: users of the levonorgestrel-releasing intrauterine system (LNG-IUS) reported reductions of up to 90%. Insertion may, however, be regarded as invasive by some women, which affects its acceptability. To determine the effectiveness, acceptability and safety of progestogen-releasing intrauterine devices in reducing heavy menstrual bleeding. We searched the Cochrane Gynaecology and Fertility Specialised Register, CENTRAL, MEDLINE, Embase, PsycINFO and CINAHL (from inception to June 2019); and we searched grey literature and for unpublished trials in ...Continue Reading


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Jul 24, 2020·The Cochrane Database of Systematic Reviews·Magdalena Bofill RodriguezJames Mn Duffy
Apr 16, 2021·Endocrinology and Metabolism·Seda Hanife Oguz, Bulent Okan Yildiz

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