PMID: 6171817Oct 1, 1981Paper

Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America
W F HahneJ D Gardner

Abstract

In dispersed acini from guinea pig pancreas, proglumide (DL-4-benzamido-N, N-dipropylglutaramic acid) and benzotript (N-p-chlorobenzoyl-L-tryptophan) caused a rightward shift in the dose--response curve for cholecystokinin-stimulated amylase secretion but did not alter the maximal increase in amylase secretion caused by cholecystokinin. At relatively low concentrations, proglumide did not alter the stimulation of enzyme secretion caused by secretagogues whose effects are mediated by adenosine 3'5'-monophosphate (e.g., vasoactive intestinal peptide or secretin) and did not alter the stimulation of enzyme secretion caused by secretagogues that have a mode of action similar to that of cholecystokinin but act through different receptors (e.g., bombesin, physalaemin, eledoisin, and ionophore A23187). There was a close correlation between the ability of proglumide or benzotript to inhibit binding of 125I-labeled cholecystokinin to its receptors on pancreatic acini and the abilities of these compounds to inhibit the action of cholecystokinin on enzyme secretion and on calcium outflux. These results indicate that proglumide and benzotript are members of a different class of cholecystokinin receptor antagonists.

References

Feb 3, 1977·The New England Journal of Medicine·S H Snyder
Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaB Brown
Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaK Birath
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R T JensenJ D Gardner
Sep 16, 1980·Biochemical and Biophysical Research Communications·P PoitrasJ H Walsh

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Citations

Jan 1, 1987·Psychopharmacology·J G CsernanskyJ Mellentin
Jan 1, 1984·Psychopharmacology·N Ben-HorinH Frenk
Mar 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·E J VerspohlI D Goldfine
Dec 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·E E VasarM O Maĭmets
Nov 1, 1993·Digestive Diseases and Sciences·M ChuK Borch
Mar 1, 1989·Digestive Diseases and Sciences·R HosotaniP L Rayford
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J MössnerW Fischbach
Aug 13, 1982·European Journal of Pharmacology·R Magous, J P Bali
Oct 1, 1984·European Journal of Pharmacology·M KnightT N Chase
Oct 22, 1985·European Journal of Pharmacology·P R NemethJ D Wood
Jan 8, 1985·European Journal of Pharmacology·G Katsuura, S Itoh
Oct 29, 1985·European Journal of Pharmacology·A J BeanG E Martin
Feb 10, 1987·European Journal of Pharmacology·I KimuraM Kimura
Jul 26, 1988·European Journal of Pharmacology·E J VerspohlH P Ammon
Oct 1, 1983·Neuropeptides·M J Sheehan, J de Belleroche
May 1, 1986·Psychiatry Research·R B InnisG R Heninger
Apr 1, 1984·Regulatory Peptides·G Shillabeer, J S Davison
Jan 1, 1986·Peptides·L H SchneiderG P Smith

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