Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy.

World Journal of Surgical Oncology
Shingo ShimadaAkinobu Taketomi

Abstract

The aim was to evaluate the prognostic factors, clinicopathological characteristics, and surgical outcomes after hepatectomy in very elderly patients with hepatocellular carcinoma (HCC). We analyzed 796 patients with HCC from 2000 to 2017. Patients aged 80 years or older were classified into the very elderly group (group VE; n = 49); patients younger than 80 years old and aged 65 years or older were classified into the elderly group (group E; n = 363), and patients younger than 65 years old were classified into the young group (group Y; n = 384). We investigated the prognoses, clinicopathological characteristics, and surgical outcomes after hepatectomy. The number of surgical procedures and outcomes, including morbidities, was not significantly different. Groups VE, E, and Y showed similar prognoses in terms of both survival and recurrence. In group VE, prothrombin activity (PA) < 80% and PIVKA-II ≥ 400 mAU/ml were unfavorable factors for survival, and PIVKA-II ≥ 400 mAU/ml and the presence of portal venous invasion (PVI), hepatic venous invasion, and fibrosis were unfavorable factors for recurrence. In group E, ChE < 180 IU/l, AFP ≥ 20 ng/ml, tumor size ≥ 10 cm, and the presence of multiple tumors, PVI, and hepatic venous inva...Continue Reading

References

Aug 28, 1986·The New England Journal of Medicine·H O AdamiB Stone
Aug 10, 2005·World Journal of Surgery·Alessandro FerreroLorenzo Capussotti
Jun 5, 2008·Journal of Gastroenterology and Hepatology·Hideki KawamuraSatoru Todo
Jul 22, 2008·World Journal of Surgery·Kazuhiro KondoJiro Ohuchida
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valérie ParadisJacques Belghiti
Mar 10, 2009·The Oncologist·Megan R Haymart
Jun 10, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jun HuangYun-Fei Yuan
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Mar 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mustafa S AschaNizar N Zein
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Seth K BechisMatthew R Cooperberg
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Nov 2, 2013·Oncology Letters·Faruk TasSenem Karabulut
Jun 14, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Katsutoshi TokushigeSusumu Higuchi
Nov 12, 2014·World Journal of Gastroenterology : WJG·Koichi OishiMikiya Kitamoto
Dec 9, 2015·Annual Review of Biomedical Engineering·Jude M PhillipDenis Wirtz
Feb 6, 2016·Geriatrics & Gerontology International·Akiyoshi KinoshitaHirokazu Nishino
Nov 20, 2016·Journal of Hepato-biliary-pancreatic Sciences·Michinori HamaokaHideki Ohdan
Dec 1, 2018·Journal of Gastroenterology·Ryosuke TateishiKazuhiko Koike
Aug 21, 2019·Clinics and Research in Hepatology and Gastroenterology·Manon Allaire, Hélène Gilgenkrantz

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