PMID: 7547217Oct 1, 1995Paper

Prognosis after salvage treatment for unselected male patients with germ cell tumours

British Journal of Cancer
A GerlW Wilmanns

Abstract

Long-term outcome of salvage treatment was reviewed in 67 unselected male patients relapsing during or after their primary cisplatin-based chemotherapy for metastatic germ cell tumours. Seven patients underwent only surgery and/or radiotherapy as curatively intended salvage treatment. Thirty-five patients (52%) had a complete or partial response to salvage treatment, 20 (57%) of whom relapsed again. With a median follow-up of 90 months (range 3-143 months) 20 patients (30%) are alive with no evidence of disease, 15 continuously disease-free and five currently disease-free. The 5 year survival from start of salvage treatment is 37% for the group as a whole. Multivariate analysis identified age < or = 35 years, complete response to primary treatment and a relapse-free interval > 3 months as independent predictors of favourable outcome of salvage treatment. A group of patients with these good-risk factors (42%) had a 5 year survival of 72% compared with the remaining patients (58%) with a 5 year survival of only 11%. Whereas patients with good-risk features may be adequately managed by conventional salvage treatment, the remaining patients carry a very poor prognosis and require innovative and more aggressive approaches.

Citations

Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Christian Kollmannsberger, Carsten Bokemeyer
Aug 20, 2008·Expert Opinion on Pharmacotherapy·C KollmannsbergerC Bokemeyer
Oct 20, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Prognostic Factors Study GroupChristian K Kollmannsberger
Sep 28, 2004·World Journal of Urology·J R SpermonL A L M Kiemeney
Sep 23, 2014·Expert Opinion on Biological Therapy·Andrea NecchiUNKNOWN European Society for Blood and Marrow Transplantation, Solid Tumors Working Party (EBMT-STWP) and the Italian Germ Cell Canc
May 16, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Kiyoshi KoshidaMikio Namiki
May 4, 2013·Journal of Cancer Research and Clinical Oncology·Tom PowlesJörg Beyer
Apr 1, 1996·Critical Reviews in Oncology/hematology·S CulineJ P Droz

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