Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): a review of the literature

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Emer O HanrahanGabriel N Hortobagyi

Abstract

Mammographic screening has led to an increase in the number of small, node-negative breast cancers being diagnosed. Node-negative breast cancers that are < or = 1 cm are stage T1a,bN0M0. Controversy surrounds the prognosis of these patients with locoregional therapy only and the need for adjuvant systemic therapy. We performed a comprehensive review of the literature describing outcome and prognostic factors in stage T1a,bN0M0 breast cancer. We also reviewed current guidelines for systemic therapy in these patients. Early studies reported 10-year relapse-free survival (RFS) rates higher than 90% without adjuvant systemic therapy, but some more recent data suggest inferior outcomes. High tumor grade is the most consistent factor associated with poor prognosis. Other adverse prognostic factors are younger age, lymphovascular invasion (LVI), high Ki-67, and larger tumors within the T1a,b subgroup. Patients with high-grade tumors and/or LVI may have 10-year RFS rates of less than 75% in the absence of systemic therapy. The prognostic significance of hormone receptor status is unclear. Current guidelines for the systemic management of early-stage breast cancer differ when applied to stage T1a,bN0M0, reflecting the controversial natu...Continue Reading

References

Aug 11, 1992·Archives of Surgery·J P CroweJ M Shuck
Mar 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P R RosenS Hellman
Sep 1, 1987·CA: a Cancer Journal for Clinicians·H SeidmanJ A Lubera
Oct 1, 1987·American Journal of Clinical Oncology·T E MoonE Montague
Jan 1, 1981·Annals of Surgery·P P RosenA DePalo
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A QuietS Hellman
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P P RosenL Norton
Jan 1, 1993·Breast Cancer Research and Treatment·D Rosner, W W Lane
Dec 9, 1997·Journal of the National Cancer Institute·B FisherR G Margolese
Mar 5, 1999·Breast Cancer Research and Treatment·S G HilsenbeckG M Clark
May 18, 1999·Cancer·H JoensuuS Toikkanen
Sep 24, 1999·Annals of Surgical Oncology·G B MannK J Van Zee
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·P L FitzgibbonsS J Schnitt
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Apr 30, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·U R Kleeberg
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard FisherUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Craig HendersonLarry Norton
Apr 28, 2004·Breast Cancer Research and Treatment·Mario SchootmanRebecca Aft
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K ChiaIvo A Olivotto
Aug 5, 2004·British Journal of Cancer·J FracheboudUNKNOWN National Evaluation Team for Breast cancer screening (NETB)
Sep 2, 2004·Journal of the National Cancer Institute·Catherine SchairerSusan S Devesa
Nov 3, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColleoniA Goldhirsch
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark

❮ Previous
Next ❯

Citations

Oct 12, 2007·Breast Cancer Research and Treatment·Emad A RakhaIan O Ellis
Dec 25, 2012·Breast Cancer Research and Treatment·I D Nagtegaal, S W Duffy
Aug 29, 2012·Pathology Oncology Research : POR·Joško BezićSnježana Tomić
Jan 19, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yukihiro Hama, Keiichi Nakagawa
Aug 25, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kazuhiro ArakiYasutsuna Sasaki
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C OakmanA Di Leo
Oct 30, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J RodriguesP H Cottu
Sep 2, 2011·Journal of the National Cancer Institute·Peer ChristiansenUNKNOWN Danish Breast Cancer Cooperative Group
Oct 10, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Graeme J KoelwynLee W Jones
Sep 11, 2008·Annals of Surgical Oncology·Yasuhiro SasakiJun-ichi Ogawa
Jan 9, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G HouvenaeghelB Esterni
Jul 23, 2014·Cancer Chemotherapy and Pharmacology·Moon Ki ChoiYoung-Hyuck Im
Jan 23, 2010·Annals of Surgical Oncology·Stella MookEmiel J Rutgers
Oct 27, 2011·Journal of Oncology·Ren-Kui BaiLee-Jun C Wong
May 29, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B J van WelyL J A Strobbe
May 21, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R G KimW C Noh
Aug 4, 2007·Mayo Clinic Proceedings·Sandhya PruthiJames N Ingle
May 22, 2007·Hematology/oncology Clinics of North America·Gustavo IsmaelMartine Piccart-Gebhart
Nov 18, 2015·Journal of Environmental Sciences (China)·Neha GuptaVinit Kumar
Dec 7, 2010·The Breast Journal·Alfonso Sánchez-MuñozEmilio Alba
Nov 5, 2011·The Breast Journal·Nicole KrekelSybren Meijer
Nov 5, 2011·The Breast Journal·Julián IturbeBernardo Leone
Sep 1, 2015·Seminars in Oncology·Gloria J MorrisDeborah Toppmeyer
Sep 12, 2012·Molecular and Cellular Endocrinology·Marie MaynadierMarcel Garcia
Mar 16, 2013·The Breast : Official Journal of the European Society of Mastology·Yazan MigdadyAdam J Olszewski
Aug 18, 2009·The Breast : Official Journal of the European Society of Mastology·I GarassinoA Santoro
Aug 9, 2016·Clinical Breast Cancer·Elena Navarro-RodríguezJavier Briceño-Delgado
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emer O HanrahanVicente Valero
May 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold J Burstein, Eric P Winer
Apr 13, 2019·International Journal of Cancer. Journal International Du Cancer·Carmen van DooijeweertIvette A G Deckers

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