Prognosis importance of low flow in aortic stenosis with preserved LVEF

Heart
Julien MagneVictor Aboyans

Abstract

Previous studies using echocardiography suggested that a low flow (LF) defined as an indexed stroke volume (SVi) <35 mL/m(2) may be an important determinant of outcome in patients with severe aortic stenosis (AS). We sought to assess the prognostic importance of stroke volume derived from invasive data. The aim of this study was to determine the impact of LF, purposely derived from cardiac catheterisation data, on outcome of patients with severe AS and preserved LVEF. Between 2000 and 2010, 768 patients with preserved LVEF (>50%) and severe AS (valve area ≤1 cm(2)) without other valvular heart disease underwent cardiac catheterisation. The long-term overall mortality was assessed as the primary end-point. Mean age was 74±8 years, 58% were men, 46% had coronary artery disease and mean LVEF was 72±10%. Low SVi was found in 27% (n=210) of patients with AS. As compared with patients with normal SVi, those with low SVi were significantly older (p<0.0001) with higher rate of atrial fibrillation (p<0.0001). Additionally, they had lower LVEF (p=0.046), aortic valve area (p<0.0001), mean pressure gradient (p<0.0001), systemic arterial compliance (p<0.0001) and higher systemic vascular resistances (p<0.0001). Eight-year survival was sign...Continue Reading

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Citations

Jan 23, 2016·Heart·Muhammad Jawad-Ul-Qamar, Paulus Kirchhof
Nov 23, 2016·Journal of Cardiovascular Medicine·Giuseppe Di PasqualeSilvia Zagnoni
Sep 9, 2017·Heart·Catherine M Otto
Feb 23, 2019·European Heart Journal Cardiovascular Imaging·Julien Magne, Victor Aboyans
Feb 15, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Julien MagneVictor Aboyans

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