Prognosis of acute-on-chronic liver failure patients treated with artificial liver support system

World Journal of Gastroenterology : WJG
Pi-Qi ZhouZhi-Hong Weng

Abstract

To establish a new model for predicting survival in acute-on-chronic liver failure (ACLF) patients treated with an artificial liver support system. One hundred and eighty-one ACLF patients who were admitted to the hospital from January 1, 2012 to December 31, 2014 and were treated with an artificial liver support system were enrolled in this retrospective study, including a derivation cohort (n = 113) and a validation cohort (n = 68). Laboratory parameters at baseline were analyzed and correlated with clinical outcome. In addition to standard medical therapy, ACLF patients underwent plasma exchange (PE) or plasma bilirubin adsorption (PBA) combined with plasma exchange. For the derivation cohort, Kaplan-Meier methods were used to estimate survival curves, and Cox regression was used in survival analysis to generate a prognostic model. The performance of the new model was tested in the validation cohort using a receiver-operator curve. The mean overall survival for the derivation cohort was 441 d (95%CI: 379-504 d), and the 90- and 270-d survival probabilities were 70.3% and 58.3%, respectively. The mean survival times of patients treated with PBA plus PE and patients treated with PE were 531 d (95%CI: 455-605 d) and 343 d (95%CI...Continue Reading

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Citations

Feb 6, 2016·Hepatology International·Rakhi Maiwall, Richard Moreau
Dec 30, 2017·Experimental and Therapeutic Medicine·Yuanli LeiYingru Lu
May 26, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Javier Ampuero
Jan 29, 2020·World Journal of Gastroenterology : WJG·Eunice Xiang-Xuan TanGuan-Huei Lee
Jul 15, 2021·Seminars in Liver Disease·Rakhi Maiwall, Shiv K Sarin

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