Prognosis of antenatally diagnosed vein of Galen aneurysmal malformations
In our experience of 168 consecutive cerebral arteriovenous shunts, all antenatally diagnosed lesions were vein of Galen aneurysmal malformations (VGAMs). This series consists of 18 cases of VGAMs detected by ultrasound during the third trimester of pregnancy. There were 12 normal vaginal deliveries, 5 deliveries by cesarean section, and 1 induced abortion. Sixteen newborns (94%) presented with systemic cardiac manifestations as the first clinical symptoms; 12/16 were managed effectively by digitalo-diuretic treatment, while 4 (25%) died shortly after birth from acute heart and/or multiorgan failure with extensive brain damage. Twelve babies underwent embolization via the arterial route in infancy (2 at 2 months of age). Total exclusion was obtained in 8 babies (67%, 3 with 6 months follow-up). Furthermore, 67% of the newborns managed by our team are neurologically normal (Denver and Brunet-Leizine tests). These results emphasize that the pessimism that follows antenatal discovery of these lesions and the previous assumption of a bad prognosis for VGAMs can nowadays be reviewed in the light of transarterial endovascular therapy applied according to a strict clinicoradiological protocol. Interventions in the neonatal period are ...Continue Reading
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Correlation of prenatal MRI and autopsy findings in the diagnosis of vein of galen arteriovenous malformation.
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Antenatal diagnosis and prognostic factors of aneurysmal malformation of the vein of Galen: A case report and literature review
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Hidden mortality of prenatally diagnosed vein of Galen aneurysmal malformation: retrospective study and review of the literature
Endovascular treatment of vein of Galen aneurysmal malformation: management strategy and 21-year experience in Toronto
Outcome and complications of endovascular embolization for vein of Galen malformations: a systematic review and meta-analysis
Predicting factors for the follow-up outcome and management decisions in vein of Galen aneurysmal malformations.
Vein of Galen aneurysmal malformation (VGAM) in the fetus: retrospective analysis of perinatal prognostic indicators in a two-center series of 49 cases
Review on the current treatment status of vein of Galen malformations and future directions in research and treatment.
Management and Outcomes of Neonatal Arteriovenous Brain Malformations with Cardiac Failure: A 17 Years' Experience in a Tertiary Referral Center
Brain Injury & Trauma
brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.