Prognosis of COPD depends on severity of exacerbation history: A population-based analysis

Respiratory Medicine
Yunus ÇolakPeter Lange

Abstract

Differences in previous exacerbation history may influence prognosis of chronic obstructive pulmonary disease (COPD). We hypothesized that prognosis differs between individuals with a history of only medically treated exacerbations (moderate exacerbations) and those with a history of hospitalised exacerbations (severe exacerbations). We included 98 614 adults from the Copenhagen General Population Study and assessed risk of moderate and severe exacerbations, pneumonia hospitalisation, and respiratory and all-cause mortality from 2003 until 2013 according to exacerbation history. Among 6545 individuals with COPD, 6290 had no exacerbations in the preceding year, 109 had one moderate exacerbation, 108 had two or more moderate exacerbations, and 38 had one or more severe exacerbations. During 9.4 years of follow-up, we observed 926 moderate and 244 severe exacerbations, 477 pneumonias, and 707 deaths, including 69 from respiratory disease. Compared to individuals without previous exacerbations, lung function and symptom adjusted hazard ratios (HRs) for future moderate exacerbation were 4.68 (95% confidence interval:3.31-6.62) for individuals with one previous moderate exacerbation, 21 (13-33) for individuals with two or more previo...Continue Reading

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Citations

Jun 13, 2020·American Journal of Respiratory and Critical Care Medicine·Guoshuai CaiChristopher I Amos
Jul 3, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Ingela HenochPeter Strang
Dec 29, 2020·PloS One·Stinna SkaabyJens Peter Ellekilde Bonde
Jun 30, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christine R Jenkins
Jul 25, 2021·International Journal of Molecular Sciences·Stanislav Kotlyarov, Anna Kotlyarova

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