Prognosis of eyelid sebaceous gland carcinoma based on the tumor (T) category of the American Joint Committee on Cancer (AJCC) classification

International Ophthalmology
Swathi KalikiMilind N Naik

Abstract

The purpose of this study was to evaluate the clinical features and prognosis of eyelid sebaceous gland carcinoma (SGC) based on the T category of the American Joint Committee on Cancer (AJCC) classification (7th edition). This is a retrospective interventional case series study. Based on the T category of the AJCC classification, 191 patients with eyelid sebaceous gland carcinoma were classified as T1 (n = 1, 1 %), T2 (n = 111, 58 %), T3 (n = 76, 40 %), and T4 (n = 3, 2 %). Based on multivariate analysis, the factors predictive of regional lymph node metastasis included duration of symptoms >6 months (p = 0.04) and orbital tumor extension (p < 0.001). The factors predictive of systemic metastasis included orbital tumor extension (p < 0.001) and perivascular invasion (p = 0.007). The factor predictive of death due to systemic metastasis included orbital tumor extension (p < 0.001). Kaplan-Meier estimates of regional lymph node metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 11 and 11 % for T2, 44 and 59 % for T3, and 100 and 100 % for T4 (p < 0.001). Kaplan-Meier estimates of systemic metastasis at 5 and 10 years, respectively, were 0 and 0 % for T1, 6 and 6 % for T2, 35 and 35 % for T3, and 100 and 100 % for...Continue Reading

References

Jan 1, 1991·Ophthalmic Plastic and Reconstructive Surgery·J A KhanA S Grove
Dec 8, 2004·Ophthalmology·Jerry A ShieldsCarol L Shields
Sep 12, 2012·Ophthalmic Plastic and Reconstructive Surgery·Carol L ShieldsJerry A Shields
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emma KujalaTero Kivelä
Sep 17, 2013·The British Journal of Ophthalmology·Akihide WatanabeDinesh Selva

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Citations

Feb 21, 2018·The British Journal of Ophthalmology·Stacey C LamHunter K L Yuen
Mar 19, 2019·The Journal of Craniofacial Surgery·Orapan AryasitNimastika Hajeewaming
Sep 1, 2019·Archives of Dermatological Research·Nour KibbiMurad Alam
Oct 2, 2019·International Ophthalmology·Tatsuya YunokiAtsushi Hayashi
Jan 21, 2020·The Australasian Journal of Dermatology·Albert WuDinesh Selva
Apr 27, 2018·International Ophthalmology·Maria Vittoria Cicinelli, Swathi Kaliki
Mar 26, 2019·International Ophthalmology Clinics·Xin SongXianqun Fan
Mar 18, 2020·Cancers·Teresa A FerreiraJan-Willem M Beenakker
Jul 14, 2019·The Journal of Craniofacial Surgery·Orapan AryasitNimastika Hajeewaming
May 26, 2018·The Australasian Journal of Dermatology·Albert WuDinesh Selva
Aug 22, 2020·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Roisin R ReynoldsValerie A White

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