Prognosis of oesophageal adenocarcinoma and squamous cell carcinoma following surgery and no surgery in a nationwide Swedish cohort study

BMJ Open
Joonas H KauppilaJesper Lagergren

Abstract

To assess the recent prognostic trends in oesophageal adenocarcinoma and oesophageal squamous cell carcinoma undergoing resectional surgery and no such surgery. Additionally, risk factors for death were assessed in each of these patient groups. Cohort study. A population-based, nationwide study in Sweden. All patients diagnosed with oesophageal adenocarcinoma and oesophageal squamous cell carcinoma in Sweden from 1 January 1990 to 31 December 2013, with follow-up until 14 May 2017. Observed and relative (to the background population) 1-year , 3-year and 5-year survivals were analysed using life table method. Multivariable Cox regression provided HR with 95% CI for risk factors of death. Among 3794 patients with oesophageal adenocarcinoma and 4631 with oesophageal squamous cell carcinoma, 82% and 63% were men, respectively. From 1990-1994 to 2010-2013, the relative 5-year survival increased from 12% to 15% for oesophageal adenocarcinoma and from 9% to 12% for oesophageal squamous cell carcinoma. The corresponding survival following surgery increased from 27% to 45% in oesophageal adenocarcinoma and from 24% to 43% in oesophageal squamous cell carcinoma. In patients not undergoing surgery, the survival increased from 3% to 4% for...Continue Reading

Citations

Sep 1, 2018·International Journal of Cancer. Journal International Du Cancer·Joonas H KauppilaJesper Lagergren
Oct 20, 2018·Annals of Surgery·Joonas H KauppilaPernilla Lagergren
Jul 3, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Olli HelminenVille Kytö
Jan 4, 2020·The American Journal of Gastroenterology·Allon KahnPrasad G Iyer
Nov 27, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Eoghan BurkeIbrahim Ahmed
Dec 5, 2019·World Journal of Gastrointestinal Endoscopy·Vedha SanghiPrashanthi N Thota
Jan 14, 2021·Acta Oncologica·Anna JunttilaOlli Helminen
Jan 20, 2021·Clinical and Translational Gastroenterology·Nathaniel WeygantKenneth J Vega
Apr 8, 2021·Annals of Surgery·Shao-Hua XieJesper Lagergren
Aug 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ella M K JokelaUNKNOWN FINEGO group
Dec 21, 2021·Acta Oncologica·Anna SchandlPernilla Lagergren

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