Prognosis of Pain and Physical Functioning in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Arthritis Care & Research
Mariëtte de RooijJoost Dekker

Abstract

To systematically summarize the literature on the course of pain in patients with knee osteoarthritis (OA), prognostic factors that predict deterioration of pain, the course of physical functioning, and prognostic factors that predict deterioration of physical functioning in persons with knee OA. A search was conducted in PubMed, CINAHL, Embase, Psych-INFO, and SPORTDiscus up to January 2014. A meta-analysis and a qualitative data synthesis were performed. Of the 58 studies included, 39 were of high quality. High heterogeneity across studies (I(2)  >90%) and within study populations (reflected by large SDs of change scores) was found. Therefore, the course of pain and physical functioning was interpreted to be indistinct. We found strong evidence for a number of prognostic factors predicting deterioration in pain (e.g., higher knee pain at baseline, bilateral knee symptoms, and depressive symptoms). We also found strong evidence for a number of prognostic factors predicting deterioration in physical functioning (e.g., worsening in radiographic OA, worsening of knee pain, lower knee extension muscle strength, lower walking speed, and higher comorbidity count). Because of high heterogeneity across studies and within study populat...Continue Reading

References

Feb 1, 1992·Annals of the Rheumatic Diseases·A JonesM Doherty
Jan 1, 1995·Annals of the Rheumatic Diseases·J LedinghamM Doherty
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 18, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·S A MazzucaG Eckert
Apr 20, 2000·Osteoarthritis and Cartilage·P DieppeL Shepstone
Jul 13, 2001·JAMA : the Journal of the American Medical Association·L SharmaD D Dunlop
Aug 28, 2001·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·W J RejeskiS Rapp
Dec 14, 2002·Osteoarthritis and Cartilage·H MirandaH Riihimäki
Feb 18, 2003·Journal of the American Geriatrics Society·Anthony P MarshStephen P Messier
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Feb 14, 2004·Annals of the Rheumatic Diseases·A E WlukaF M Cicuttini
Dec 14, 2004·Arthritis and Rheumatism·Alison ChangLeena Sharma
Mar 22, 2006·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
Oct 3, 2006·Arthritis and Rheumatism·Gabriella M van DijkUNKNOWN Carpa Study Group
Dec 13, 2006·Annals of the Rheumatic Diseases·S AminD T Felson
Jan 11, 2008·Journal of the American Geriatrics Society·Kenneth E CovinskyEdward Yelin
Feb 5, 2008·Annals of the Rheumatic Diseases·M BlagojevicK P Jordan
Mar 12, 2008·Journal of General Internal Medicine·Daniel P AlfordMatthew J Bair
Sep 30, 2008·Arthritis and Rheumatism·Angela K LangeMaria A Fiatarone Singh
Jan 1, 2009·Arthritis and Rheumatism·Shreyasee AminDavid T Felson
Jun 25, 2009·Current Opinion in Rheumatology·Joost DekkerCindy Veenhof
Jul 30, 2009·The Journal of Pain : Official Journal of the American Pain Society·George Peat, Elaine Thomas
Dec 2, 2009·Arthritis and Rheumatism·Kirsten MoisioLeena Sharma
Jan 28, 2010·Archives of Physical Medicine and Rehabilitation·Gabriella M van DijkUNKNOWN CARPA Study Group
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
May 4, 2010·Archives of Physical Medicine and Rehabilitation·Dorothy D DunlopUNKNOWN Osteoarthritis Initiative Investigators
May 28, 2010·Arthritis Care & Research·Daniel K WhiteTuhina Neogi
Jun 15, 2011·Arthritis Care & Research·Marlous KasteleinSita M A Bierma-Zeinstra
Nov 25, 2011·BMC Musculoskeletal Disorders·Gabriella M van DijkJoost Dekker

❮ Previous
Next ❯

Citations

Sep 28, 2017·Pain Practice : the Official Journal of World Institute of Pain·Man HungMaren W Voss
Feb 17, 2018·British Journal of Sports Medicine·Reed A C SiemieniukAnnette Kristiansen
Sep 14, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Kathryn MillsDavid J Hunter
Jan 21, 2018·BMC Musculoskeletal Disorders·Tomoko FujiiKo Matsudaira
Apr 6, 2019·The Clinical Journal of Pain·Peter SkrejborgLars Arendt-Nielsen
Sep 6, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·I A R KuijlaarsK Fischer
Oct 4, 2019·Journal of Clinical Ultrasound : JCU·Kyösti KauppinenMika T Nevalainen
Apr 7, 2020·The Journal of Bone and Joint Surgery. American Volume·Samantha M MeintsKristin L Schreiber
Oct 19, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Leslie R M HausmannAcacia Parks
Mar 14, 2018·Journal of Geriatric Physical Therapy·Kai-Yu HoSkyler Sudweeks
Jan 16, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K K LimJ S B Koh
Aug 4, 2020·BMC Musculoskeletal Disorders·Wen-Ling YehChing-Yen Chen
Sep 10, 2019·Therapeutic Advances in Musculoskeletal Disease·Venta Donec, Raimondas Kubilius
Jun 27, 2019·Journal of Gerontological Nursing·Myung Kyung Lee, Ji Hyun Oh
Jul 25, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Birgitta Gatenholm, Mats Brittberg
Oct 31, 2020·Pain Management·Marina Fayet, Martina Hagen
Aug 20, 2021·Physiotherapy Theory and Practice·Abdurrahman NalbantVasfi Karatosun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.