PMID: 26336791Sep 5, 2015Paper

Prognosis of Papillary Thyroid Carcinoma with Local Invasion

Nihon Jibiinkoka Gakkai kaiho
Koichiro YamadaMasayoshi Yoshimatsu

Abstract

The aim of this study was to detect prognostic factors in patients with locally advanced papillary thyroid carcinoma. The study included 72 patients (T4a/T4b 72/0, N0/N1a/N1b 25/15/32, M0/M1 68/4, mean follow-up 8.1 4.4 years) who underwent initial surgical treatment at Osaka Red Cross Hospital between April 1993 and April 2011. Eleven patients died of PTC, 3 patients with recurrence died of unrelated disease and 10 patients are alive with recurrence. The overall 5-year survival rate was 88.3%, and the 10-year survival rate was 73.4%. The disease-specific 5-year survival rate was 91.4%, and the 10-year survival rate was 88.6%. The 5-year local control rate was 94.1%, and the 10-year local control rate was 85.4%. Patients with distant metastasis (M1), tracheal invasion and/or multiple organs invasion showed a significantly worse disease-specific survival rate based on a univariate analysis, which also revealed that tracheal invasion, laryngeal invasion, esophageal invasion and multiple organs invasion were risk factors linked to the development of distant metastasis during follow-up (recurrence as distant metastasis). The following were found to be clinically significant risk factors, based on the multivariate analysis among tra...Continue Reading

References

Aug 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D P ByarM van Glabbeke

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Citations

Jun 14, 2019·European Thyroid Journal·Kirsten E StewartIain J Nixon

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