Prognosis of patients excluded by the definition of septic shock based on their lactate levels after initial fluid resuscitation: a prospective multi-center observational study

Critical Care : the Official Journal of the Critical Care Forum
Byuk Sung KoKorean Shock Society (KoSS) Investigators

Abstract

Septic shock can be defined both by the presence of hyperlactatemia and need of vasopressors. Lactate levels should be measured after volume resuscitation (as per the Sepsis-3 definition). However, currently, no studies have evaluated patients who have been excluded by the new criteria for septic shock. The aim of this study was to determine the clinical characteristics and prognosis of these patients, based on their lactate levels after initial fluid resuscitation. This observational study was performed using a prospective, multi-center registry of septic shock, with the participation of 10 hospitals in the Korean Shock Society, between October 2015 and February 2017. We compared the 28-day mortality between patients who were excluded from the new definition (defined as lactate level <2 mmol/L after volume resuscitation) and those who were not (≥2 mmol/L after volume resuscitation), from among a cohort of patients with refractory hypotension, and requiring the use of vasopressors. Other outcome variables such as in-hospital mortality, intensive care unit (ICU) stay (days), Sequential Organ Failure Assessment (SOFA) scores and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were also analyzed. Of 567 patients ...Continue Reading

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Citations

Jan 15, 2019·Journal of Intensive Care Medicine·Shuhei TakaujiSatoshi Fujita
Jul 11, 2020·European Journal of Clinical Investigation·Francisco Martín-RodríguezAncor Sanz-García
Feb 6, 2021·Journal of Clinical Medicine·Byuk Sung KoWon Young Kim
Nov 2, 2020·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Kevin B Laupland, Fiona Coyer
Oct 18, 2019·The American Journal of Medicine·Byuk Sung KoUNKNOWN Korean Shock Society (KoSS) Investigators
Jun 3, 2021·International Journal of Environmental Research and Public Health·Won Soek YangWon Young Kim
Jul 6, 2021·The American Journal of Emergency Medicine·Francisco Martín-RodríguezRaúl López-Izquierdo
Oct 24, 2020·The American Journal of Emergency Medicine·Gun Tak LeeUNKNOWN Korean Shock Society (KoSS) investigators
Oct 5, 2021·Internal and Emergency Medicine·Sang-Min KimUNKNOWN Korean Shock Society (KoSS) Investigators

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