Abstract
Three new therapies have been approved recently for the adjuvant treatment of stage III melanoma, substantially reducing the risk of tumor recurrences. This study evaluates 3 independent data sets to clarify the survival probabilities of patients with stage III melanoma. The Central Malignant Melanoma Registry (CMMR) evaluated 1,553 patients with a primary diagnosis of stage III melanoma from 2000 to 2012. Studies from the European Organisation for Research and Treatment of Cancer (EORTC), of 573 patients in the observation arm of the 18991 study and 445 patients in the placebo arm of the 18071 study, were evaluated as reference cohorts. The survival outcomes were compared with the published American Joint Committee on Cancer version 8 (AJCCv8) stage III survival data. For the CMMR stage III cohort versus the AJCCv8 cohort, the melanoma-specific survival (MSS) rates at 5 years were 67% versus 77%, and at 10 years were 56% versus 69%, respectively. For stage IIIA, the MSS rates at 5 years were 80% versus 93%, and at 10 years were 71% versus 88%; for stage IIIB, the MSS rates at 5 years were 75% versus 83%, and at 10 years were 61% versus 77%. The MSS rates of the EORTC studies either overlapped with or were lower than, the CMMR ...Continue Reading
References
Sep 26, 2000·Cancer·C GarbeP G Buettner
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Jul 16, 2008·Lancet·Alexander Mm EggermontUNKNOWN EORTC Melanoma Group
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Aug 23, 2011·Journal of Surgical Oncology·Charles M BalchJohn F Thompson
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander M M EggermontUlrich Keilholz
Apr 5, 2015·The Lancet Oncology·Alexander M M EggermontAlessandro Testori
Nov 26, 2015·Cancer Treatment and Research·Genevieve M Boland, Jeffrey E Gershenwald
Dec 29, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Selma UgurelClaus Garbe
Oct 9, 2016·The New England Journal of Medicine·Alexander M M EggermontAlessandro Testori
Aug 2, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Selma UgurelClaus Garbe
Sep 12, 2017·The New England Journal of Medicine·Georgina V LongJohn M Kirkwood
Sep 12, 2017·The New England Journal of Medicine·Jeffrey WeberUNKNOWN CheckMate 238 Collaborators
Oct 14, 2017·CA: a Cancer Journal for Clinicians·Jeffrey E GershenwaldUNKNOWN for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Disc
Dec 12, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean Jacques GrobClaus Garbe
Feb 15, 2018·The New England Journal of Medicine·Frank C SciurbaIan D Pavord
Feb 16, 2018·The New England Journal of Medicine·Parichehr Shahlavi‑Monavvar, Abdolkarim Mobasher-Jannat
Apr 17, 2018·The New England Journal of Medicine·Alexander M M EggermontCaroline Robert
Jun 1, 2018·Nature Reviews. Clinical Oncology·Alexander M M EggermontAntoni Ribas
Jun 1, 2018·Annals of Surgical Oncology·Jeffrey E Gershenwald, Richard A Scolyer
Jun 30, 2018·Cancer Treatment Reviews·S NapolitanoT Troiani
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Ragini R KudchadkarAlexander C J van Akkooi
Oct 15, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·E CrocettiN Pimpinelli
Nov 6, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C GarbeU Leiter
Dec 7, 2018·The Lancet Oncology·Jean Jacques GrobDirk Schadendorf
Dec 24, 2018·Journal of Surgical Oncology·Joseph G CromptonMary S Brady
May 22, 2019·Annals of Surgical Oncology·Karolin IsakssonRoger Olofsson Bagge
Aug 11, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander M M EggermontAlessandro Testori
Aug 12, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Theodora KanakiElisabeth Livingstone
Citations
Oct 24, 2020·Expert Review of Anticancer Therapy·Tharani KrishnanRachel Roberts-Thomson
Jan 1, 2021·Critical Reviews in Oncology/hematology·Stergios BoussiosNicholas Pavlidis
Jan 26, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander M M EggermontCaroline Robert
Feb 14, 2021·Annales de dermatologie et de vénéréologie·E Funck-BrentanoP Saiag
Mar 28, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F DimitriouA M Menzies
Jun 3, 2021·Cancers·Georg LoddeElisabeth Livingstone
Jun 3, 2021·Cancers·Hanna ErikssonTherese M-L Andersson
Jun 9, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne ZarembaElisabeth Livingstone
Dec 4, 2020·Annales de dermatologie et de vénéréologie·H Montaudié
Nov 24, 2021·Asia-Pacific Journal of Clinical Oncology·Angelina TjokrowidjajaHussein Soudy