Prognosis of the individual course of disease: the elements of time, heterogeneity and precision

Journal of the Neurological Sciences
Martin DaumerG C Ebers

Abstract

There is no gold standard in monitoring disease activity for clinical trials in multiple sclerosis. Various outcome measures, including relapses, disability and magnetic resonance imaging (MRI) measures have been used to demonstrate the efficacy of the different available therapies for multiple sclerosis. Recently, the potential limitations of these measures have received increasing attention, and these have stimulated research into more appropriate and sensitive outcome measures for clinical trials. For example, it has been shown that widely-used MRI measures add little, if any, independent information to that provided by more clinically relevant measures such as relapses and disability. Similarly, the Expanded Disability status Scale (EDSS), which is the most widely-used measure of disability related to multiple sclerosis, is insufficiently sensitive to detect robust changes in disability over the timeframes usually used in clinical trials. An alternative to the EDSS is the Multiple Sclerosis Severity Score (MSSS), a severity scale which relates clinical disability to disease duration. The MSSS was originally developed from a database of nearly ten thousand patients from eleven European countries and Australia and has since b...Continue Reading

References

May 10, 2007·BMC Medical Informatics and Decision Making·M DaumerUNKNOWN Sylvia Lawry Centre for Multiple Sclerosis Research
May 16, 2008·Neurology·G C EbersJ H Noseworthy

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Citations

Mar 9, 2012·BMC Neurology·Dana HorakovaOndrej Dolezal
Jun 10, 2011·Genes and Immunity·UNKNOWN International Multiple Sclerosis Genetics Consortium
May 23, 2013·Journal of the Neurological Sciences·O Fernández
Aug 24, 2010·Arquivos de neuro-psiquiatria·Lineu Cesar WerneckRosana Herminia Scola
Dec 8, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Mohsen KhademiTomas Olsson
May 1, 2012·Neurorehabilitation and Neural Repair·Jennifer L KellerKathleen M Zackowski
Mar 21, 2012·Acta Neurologica Scandinavica·D HorakovaE Havrdova
Jan 23, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Ilya Kister, Orhun H Kantarci
Mar 14, 2012·Current Opinion in Neurology·Gavin Giovannoni, Robert W Rhoades
Aug 25, 2019·Journal of Neuroengineering and Rehabilitation·H E M BraakhuisUNKNOWN TREFAMS-ACE study group
Jun 25, 2019·Journal of Managed Care & Specialty Pharmacy·Elizabeth C S SwartNatasha Parekh

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