Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Janette C CansickC Mark Taylor

Abstract

Prognostic factors and outcome are incompletely known in childhood mesangiocapillary glomerulonephritis (MCGN). This study aimed to correlate renal outcome with clinical and histopathological variables. We conducted a two-centre retrospective analysis of children with MCGN. Fifty-three children presented at a mean age of 8.8 years (range: 13 months-15 years). They were followed for a median of 3.5 years (range: 0-17 years). Histological classification identified 31 type 1, 14 type 2, two type 3 and six undetermined type. Mean renal survival [time to end-stage renal failure (ESRF)] was projected to be 12.2 years [confidence interval (CI): 9.7-14.6 years]. Five and 10 year renal survival was 92% (CI: 88-100%) and 83% (CI: 74-92%), respectively. Those with nephrotic syndrome at presentation had mean renal survival of 8.9 years (CI: 7.1-10.7 years) vs 13.6 years for those without (CI: 10.8-16.5 years) (P = 0.047). The mean estimated glomerular filtration rate (eGFR) at 1 year in those who progressed to ESRF was 52 vs 98 ml/min/1.73 m2 in those who did not (P < 0.001). Chronic damage scored on the first biopsy in 31 children (one centre) was positively associated with adverse renal outcome at 5 years: <20% was associated with 100% a...Continue Reading

Citations

Jul 5, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maha HaddadLavjay Butani
Nov 13, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bassam Alchi, David Jayne
Nov 4, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Thomas J NeuhausAndreas Fischer
Nov 23, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Der-Fa LuRichard J H Smith
Jan 5, 2014·European Journal of Pediatrics·Julianne PrastoKevin E C Meyers
Jun 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jameela A KariStephen D Marks
Feb 26, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Silvestre García-de la PuenteBeatriz de Leon Bojorge
Jul 16, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sally Ann JohnsonC Mark Taylor
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Oct 29, 2013·Seminars in Nephrology·Thomas D BarbourH Terence Cook
Jan 13, 2018·Seminars in Immunopathology·Edwin K S Wong, David Kavanagh

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